Molecule Information

General Information of the Molecule (ID: Mol02208)

• Name: Long non-protein coding RNA (RP11-138 J23.1) ,Homo sapiens
• Synonyms: RP11-138 J23.1
• Molecule Type: LncRNA
• Gene Name: RP11-138 J23.1

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Investigative Drug(s) 1 drug(s) in total

N6-Methyladenosine

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Colorectal cancer [1]

• Resistant Disease: Colorectal cancer [ICD-11: 2B91.1]
• Resistant Drug: N6-Methyladenosine
• Molecule Alteration: Up-regulation; Expression
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Colorectal cancer tissue; .
• In Vivo Model: BALB/c nude mice model; Mus musculus
• Experiment for Molecule Alteration: Microarray assay
• Mechanism Description: M6A-induced LncRNA RP11 triggers the dissemination of colorectal cancer cells via upregulation of Zeb1.

References

• Ref 1: m(6)A-induced lncRNA RP11 triggers the dissemination of colorectal cancer cells via upregulation of Zeb1Mol Cancer. 2019 Apr 13;18(1):87. doi: 10.1186/s12943-019-1014-2.