Molecule Information

General Information of the Molecule (ID: Mol02198)
Name
SIRT1 antisense RNA (SIRT1-AS) ,Homo sapiens
Synonyms
SIRT1-AS
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Molecule Type
LncRNA
Gene Name
SIRT1-AS
Gene ID
106633813
HGNC ID
HGNC:51912
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Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Type(s) of Resistant Mechanism of This Molecule
  EADR: Epigenetic Alteration of DNA, RNA or Protein
Drug Resistance Data Categorized by Drug
Investigative Drug(s)
1 drug(s) in total
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Astragaloside IV
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Disease Class: Pulmonary fibrosis [1]
Resistant Disease Pulmonary fibrosis [ICD-11: CB03.1]
 Disease Info 
Resistant Drug Astragaloside IV
 Drug Info 
Molecule Alteration Down-regulation
Expression
Experimental Note Discovered Using In-vivo Testing Model
In Vitro Model RLE-6TN cells Lung Rattus norvegicus (Rat) CVCL_4693
Experiment for
Molecule Alteration		 Overexpression assay; Knockdown assay
Experiment for
Drug Resistance		 CCK8 assay
Mechanism Description Collectively, sirt1 AS was critical for ASV-mediated inhibition of IPF progression and targeting of sirt1 AS by ASV could be a potential therapeutic approach for IPF.
References
Ref 1 Sirt1 antisense long non-coding RNA attenuates pulmonary fibrosis through sirt1-mediated epithelial-mesenchymal transitionAging (Albany NY). 2020 Mar 6;12(5):4322-4336. doi: 10.18632/aging.102882. Epub 2020 Mar 6.

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