Molecule Information

General Information of the Molecule (ID: Mol02196)

Name	Long non-protein coding RNA 1391 (LINC01391) ,Homo sapiens
Synonyms	LINC01391 Click to Show/Hide
Molecule Type	LncRNA
Gene Name	LINC01391
Gene ID	103344930
Location	chr3:138,935,189-138,944,020[-]
Ensembl ID	ENSG00000244578
HGNC ID	HGNC:50666
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Preclinical Drug(s)

1 drug(s) in total

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Piperlongumine

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Cholangiocarcinoma				[1]
Resistant Disease	Cholangiocarcinoma [ICD-11: 2C12.0]			Disease Info
Resistant Drug	Piperlongumine			Drug Info
Molecule Alteration	Down-regulation		Interaction
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Wnt/Beta-catenin signaling pathway		Inhibition	hsa04310
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	SMMC-7721 cells	Uterus	Homo sapiens (Human)	CVCL_0534
In Vivo Model	Nude mice model			Mus musculus
Experiment for Molecule Alteration	Microarray assay; qRT-PCR; RNA pull down assay; RIP experiments assay; Knockdown assay; Overexpression assay
Experiment for Drug Resistance	CCK8 assay
Mechanism Description	Piplartine suppresses proliferation and invasion of hepatocellular carcinoma by LINC01391-modulated Wnt/beta-catenin pathway inactivation through ICAT.

Disease- and Tissue-specific Abundances of This Molecule

ICD Disease Classification 02

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Liver cancer [ICD-11: 2C12]

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Differential expression of molecule in resistant diseases
The Studied Tissue	Liver
The Specified Disease	Liver hepatocellular carcinoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 5.19E-01; Fold-change: -1.27E-01
Molecule expression in the diseased tissue of patients Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances		Click to View the Clearer Original Diagram
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Tissue-specific Molecule Abundances in Healthy Individuals

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Download the Tissue-Specific Variation(s) Profile

References

Ref 1	Piplartine suppresses proliferation and invasion of hepatocellular carcinoma by LINC01391-modulated Wnt/Beta-catenin pathway inactivation through ICATCancer Lett. 2019 Sep 28;460:119-127. doi: 10.1016/j.canlet.2019.06.008. Epub 2019 Jun 14.