Molecule Information

General Information of the Molecule (ID: Mol02189)

Name	Long non-protein coding RNA 707 (LINC00707) ,Homo sapiens
Synonyms	LINC00707 Click to Show/Hide
Molecule Type	LncRNA
Gene Name	LINC00707
Gene ID	100507127
Location	chr10:6,779,549-6,879,450[+]
Ensembl ID	ENSG00000238266
HGNC ID	HGNC:44691
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Investigative Drug(s)

1 drug(s) in total

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Cisplatinum

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Lung adenocarcinoma				[1]
Resistant Disease	Lung adenocarcinoma [ICD-11: 2C25.0]			Disease Info
Resistant Drug	Cisplatinum			Drug Info
Molecule Alteration	Up-regulation		Interaction
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	A549 cells	Lung	Homo sapiens (Human)	CVCL_0023
Experiment for Molecule Alteration	qRT-PCR; Western bloting analysis; Luciferase assay; Knockdown assay
Experiment for Drug Resistance	MTT assay
Mechanism Description	Silencing long intergenic non-coding RNA 00707 enhances cisplatin sensitivity in cisplatin-resistant non-small-cell lung cancer cells by sponging miR-145.

Disease- and Tissue-specific Abundances of This Molecule

ICD Disease Classification 02

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Lung cancer [ICD-11: 2C25]

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Differential expression of molecule in resistant diseases
The Studied Tissue	Lung
The Specified Disease	Lung adenocarcinoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.07E-09; Fold-change: -7.55E-01
Molecule expression in the diseased tissue of patients Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances		Click to View the Clearer Original Diagram
Download Molecule expression barchart for all samples Download Molecule expression data of patients in the disease section of the tissue Download Molecule expression data in the tissue of healthy individual
The Studied Tissue	Lung
The Specified Disease	Lung squamous cell carcinoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 3.71E-15; Fold-change: -6.80E-01
Molecule expression in the diseased tissue of patients Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances		Click to View the Clearer Original Diagram
Download Molecule expression barchart for all samples Download Molecule expression data of patients in the disease section of the tissue Download Molecule expression data in the tissue of healthy individual

Tissue-specific Molecule Abundances in Healthy Individuals

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Download the Tissue-Specific Variation(s) Profile

References

Ref 1	Silencing long intergenic non-coding RNA 00707 enhances cisplatin sensitivity in cisplatin-resistant non-small-cell lung cancer cells by sponging miR-145Oncol Lett. 2019 Dec;18(6):6261-6268. doi: 10.3892/ol.2019.10959. Epub 2019 Oct 3.