Molecule Information

General Information of the Molecule (ID: Mol02188)

• Name: MELTF antisense RNA 1 (MELTF-AS1) ,Homo sapiens
• Synonyms: MELTF-AS1
• Molecule Type: LncRNA
• Gene Name: MELTF-AS1
• Gene ID: 100507057
• Location: chr3:196,999,460-197,004,744[+]
• Ensembl ID: ENSG00000228109
• HGNC ID: HGNC:40373

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Investigative Drug(s) 1 drug(s) in total

Lipopolysaccharide

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Streptococcus agalactiae inection [1]

• Resistant Disease: Streptococcus agalactiae inection [ICD-11: FB84.0]
• Resistant Drug: Lipopolysaccharide
• Molecule Alteration: Up-regulation; Interaction
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: C-28/I2 cells; Rib; Homo sapiens (Human); CVCL_0187
• Experiment for Molecule Alteration: Knockdown assay; Overexpression assay; qRT-PCR; Western bloting analysis; Enzyme-linked immunosorbent assay; Luciferase assay; RNA immunoprecipitation
• Experiment for Drug Resistance: MTT assay
• Mechanism Description: Knockdown of MFI2-AS1 increased cell viability but suppressed apoptosis, inflammatory response and extracellular matrix degradation in LPS-treated chondrocytes by increasing miR-130a-3p and decreasing TCF4, indicating a novel target for the treatment of osteoarthritis.

References

• Ref 1: Knockdown of lncRNA MFI2-AS1 inhibits lipopolysaccharide-induced osteoarthritis progression by miR-130a-3p/TCF4Life Sci. 2020 Jan 1;240:117019. doi: 10.1016/j.lfs.2019.117019. Epub 2019 Oct 31.