Molecule Information

General Information of the Molecule (ID: Mol02182)

Name	GABPB1 antisense RNA 1 (GABPB1-AS1) ,Homo sapiens
Synonyms	GABPB1-AS1 Click to Show/Hide
Molecule Type	LncRNA
Gene Name	GABPB1-AS1
Gene ID	100129387
Ensembl ID	ENSG00000244879
HGNC ID	HGNC:44157
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Patented Agent(s)

1 drug(s) in total

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Erastin

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Cholangiocarcinoma				[1]
Resistant Disease	Cholangiocarcinoma [ICD-11: 2C12.0]			Disease Info
Resistant Drug	Erastin			Drug Info
Molecule Alteration	Down-regulation		Interaction
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hep3B cells	Liver	Homo sapiens (Human)	CVCL_0326
	Huh7 cells	Kidney	Homo sapiens (Human)	CVCL_U442
Experiment for Drug Resistance	CCK8 assay
Mechanism Description	LncRNA GABPB1-AS1 and GABPB1 regulate oxidative stress during erastin-induced ferroptosis in HepG2 hepatocellular carcinoma cells.

Disease- and Tissue-specific Abundances of This Molecule

ICD Disease Classification 02

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Liver cancer [ICD-11: 2C12]

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Differential expression of molecule in resistant diseases
The Studied Tissue	Bile duct
The Specified Disease	Cholangiocarcinoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.56E-02; Fold-change: -9.63E-02
Molecule expression in the diseased tissue of patients Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances		Click to View the Clearer Original Diagram
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The Studied Tissue	Liver
The Specified Disease	Liver hepatocellular carcinoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 4.51E-01; Fold-change: -9.41E-03
Molecule expression in the diseased tissue of patients Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances		Click to View the Clearer Original Diagram
Download Molecule expression barchart for all samples Download Molecule expression data of patients in the disease section of the tissue Download Molecule expression data in the tissue of healthy individual

Tissue-specific Molecule Abundances in Healthy Individuals

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Download the Tissue-Specific Variation(s) Profile

References

Ref 1	LncRNA GABPB1-AS1 and GABPB1 regulate oxidative stress during erastin-induced ferroptosis in HepG2 hepatocellular carcinoma cellsSci Rep. 2019 Nov 7;9(1):16185. doi: 10.1038/s41598-019-52837-8.