Molecule Information

General Information of the Molecule (ID: Mol02176)
Name
Taurine up-regulated 1 (TUG1) ,Mus musculus
Synonyms
Tug1
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Molecule Type
LncRNA
Gene Name
Tug1
Gene ID
544752
Location
chr11:3,589,785-3,599,673[-]
Ensembl ID
ENSMUSG00000056579
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Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
Type(s) of Resistant Mechanism of This Molecule
  EADR: Epigenetic Alteration of DNA, RNA or Protein
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
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Hydrogen peroxide
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Disease Class: Myocardial infarction [1]
Resistant Disease Myocardial infarction [ICD-11: BA41.0]
 Disease Info 
Resistant Drug Hydrogen peroxide
 Drug Info 
Molecule Alteration Up-regulation
Interaction
Experimental Note Discovered Using In-vivo Testing Model
Cell Pathway Regulation miR-9/KLF5 signaling pathway Inhibition hsa05206
Experiment for
Molecule Alteration		 Luciferase assay; Knockdown assay; Overexpression assay
Experiment for
Drug Resistance		 MTT assay
Mechanism Description The long non-coding RNA TUG1-miR-9a-5p axis contributes to ischemic injuries by promoting cardiomyocyte apoptosis via targeting KLF5.
References
Ref 1 The long non-coding RNA TUG1-miR-9a-5p axis contributes to ischemic injuries by promoting cardiomyocyte apoptosis via targeting KLF5Cell Death Dis. 2019 Dec 2;10(12):908. doi: 10.1038/s41419-019-2138-4.

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