Molecule Information

General Information of the Molecule (ID: Mol02175)
Name
Growth arrest associated LncRNA 1 (GASAL1) ,Homo sapiens
Synonyms
GASAL1
    Click to Show/Hide
Molecule Type
LncRNA
Gene Name
GASAL1
Gene ID
401472
HGNC ID
HGNC:53461
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Type(s) of Resistant Mechanism of This Molecule
  EADR: Epigenetic Alteration of DNA, RNA or Protein
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
Click to Show/Hide the Full List of Drugs
Hydrogen peroxide
Click to Show/Hide
Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Disease Class: Chronic heart failure [1]
Resistant Disease Chronic heart failure [ICD-11: BD10.2]
 Disease Info 
Resistant Drug Hydrogen peroxide
 Drug Info 
Molecule Alteration Down-regulation
Expression
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model AC16 cells Heart Homo sapiens (Human) CVCL_4U18
Experiment for
Molecule Alteration		 ELISA assay; qRT-PCR; Western bloting analysis; Overexpression assay
Experiment for
Drug Resistance		 Flow cytometry assay
Mechanism Description LncRNA GASL1 is downregulated in chronic heart failure and regulates cardiomyocyte apoptosis.
References
Ref 1 LncRNA GASL1 is downregulated in chronic heart failure and regulates cardiomyocyte apoptosisCell Mol Biol Lett. 2019 Jun 13;24:41. doi: 10.1186/s11658-019-0165-x. eCollection 2019.

If you find any error in data or bug in web service, please kindly report it to Dr. Sun and Dr. Zhang.