Molecule Information

General Information of the Molecule (ID: Mol02172)

Name	HNF1A antisense RNA 1 (HNF1A-AS1) ,Homo sapiens
Synonyms	HNF1A-AS1 Click to Show/Hide
Molecule Type	LncRNA
Gene Name	HNF1A-AS1
Gene ID	283460
Location	chr12:120,941,728-120,980,968[-]
Ensembl ID	ENSG00000241388
HGNC ID	HGNC:26785
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Acetaminophen

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Cholangiocarcinoma				[1]
Resistant Disease	Cholangiocarcinoma [ICD-11: 2C12.0]			Disease Info
Resistant Drug	Acetaminophen			Drug Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepaRG cells	Liver	Homo sapiens (Human)	CVCL_9720
Experiment for Molecule Alteration	Knockdown assay
Experiment for Drug Resistance	MTT assay
Mechanism Description	Altogether, our study suggests that HNF1alpha-AS1 and HNF4alpha-AS1 affected AILI mainly through alterations of P450-mediated APAP biotransformation in HepaRG cells, indicating an important role of the LncRNAs in AILI.

Disease- and Tissue-specific Abundances of This Molecule

ICD Disease Classification 02

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Liver cancer [ICD-11: 2C12]

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Differential expression of molecule in resistant diseases
The Studied Tissue	Bile duct
The Specified Disease	Cholangiocarcinoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.95E-01; Fold-change: -7.09E-02
Molecule expression in the diseased tissue of patients Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances		Click to View the Clearer Original Diagram
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The Studied Tissue	Liver
The Specified Disease	Liver hepatocellular carcinoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.16E-15; Fold-change: -1.05E-01
Molecule expression in the diseased tissue of patients Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances		Click to View the Clearer Original Diagram
Download Molecule expression barchart for all samples Download Molecule expression data of patients in the disease section of the tissue Download Molecule expression data in the tissue of healthy individual

Tissue-specific Molecule Abundances in Healthy Individuals

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Download the Tissue-Specific Variation(s) Profile

References

Ref 1	Knockdown of Long Noncoding RNAs Hepatocyte Nuclear Factor 1Alpha Antisense RNA 1 and Hepatocyte Nuclear Factor 4Alpha Antisense RNA 1 Alters Susceptibility of Acetaminophen-Induced Cytotoxicity in HepaRG CellsMol Pharmacol. 2020 Apr;97(4):278-286. doi: 10.1124/mol.119.118778. Epub 2020 Feb 6.