Molecule Information

General Information of the Molecule (ID: Mol02168)

• Name: AFAP1 antisense RNA 1 (AFAP1-AS1) ,Homo sapiens
• Synonyms: AFAP1-AS1
• Molecule Type: LncRNA
• Gene Name: AFAP1-AS1
• Gene ID: 84740
• Location: chr4:7,754,077-7,778,928[+]
• Ensembl ID: ENSG00000272620
• HGNC ID: HGNC:28141

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  RTDM: Regulation by the Disease Microenvironment

Drug Resistance Data Categorized by Drug

Investigative Drug(s) 1 drug(s) in total

DX-8951

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Regulation by the Disease Microenvironment (RTDM)

Disease Class: Breast adenocarcinoma [1]

• Resistant Disease: Breast adenocarcinoma [ICD-11: 2C60.1]
• Resistant Drug: DX-8951
• Molecule Alteration: Up-regulation; Interaction
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: BT474 cells; Breast; Homo sapiens (Human); CVCL_0179
• In Vitro Model: SK-BR-3 cells; Pleural effusion; Homo sapiens (Human); CVCL_0033
• In Vivo Model: Male BALB/c nude mice model; Mus musculus
• Experiment for Molecule Alteration: Knockdown assay; Microarray assay; Immunoprecipitation; FISH assay; qRT-PCR
• Experiment for Drug Resistance: CCK8 assay
• Mechanism Description: Exosomal AFAP1-AS1 could induce trastuzumab resistance through associating with AUF1 and promoting ERBB2 translation. Therefore, AFAP1-AS1 level may be useful for prediction of trastuzumab resistance and breast cancer treatment.

References

• Ref 1: Exosome-mediated lncRNA AFAP1-AS1 promotes trastuzumab resistance through binding with AUF1 and activating ERBB2 translationMol Cancer. 2020 Feb 5;19(1):26. doi: 10.1186/s12943-020-1145-5.