Molecule Information

General Information of the Molecule (ID: Mol02157)

• Name: Growth arrest specific 5 (GAS5) ,Mus musculus
• Synonyms: Gas5
• Molecule Type: LncRNA
• Gene Name: Gas5
• Gene ID: 14455
• Location: chr1:160,861,992-160,866,116[+]

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Discontinued Drug(s) 1 drug(s) in total

Urethane

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Lung adenocarcinoma [1]

• Resistant Disease: Lung adenocarcinoma [ICD-11: 2C25.0]
• Resistant Drug: Urethane
• Molecule Alteration: Down-regulation; Expression
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: 16HBE cells; Lung; Homo sapiens (Human); CVCL_0112
• In Vivo Model: BALB/c nude mice model; Mus musculus
• Experiment for Molecule Alteration: Overexpression assay
• Experiment for Drug Resistance: EdU assay
• Mechanism Description: Low Long Noncoding RNA Growth Arrest-Specific Transcript 5 Expression in the Exosomes of Lung Cancer Cells Promotes Tumor Angiogenesis.

References

• Ref 1: Low Long Noncoding RNA Growth Arrest-Specific Transcript 5 Expression in the Exosomes of Lung Cancer Cells Promotes Tumor AngiogenesisJ Oncol. 2019 May 2;2019:2476175. doi: 10.1155/2019/2476175. eCollection 2019.