Molecule Information
General Information of the Molecule (ID: Mol02128)
Type(s) of Resistant Mechanism of This Molecule
UAPP: Unusual Activation of Pro-survival Pathway
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
Imatinib
Drug Resistance Data Categorized by Their Corresponding Mechanisms | ||||
Unusual Activation of Pro-survival Pathway (UAPP) | ||||
Disease Class: Dermatofibrosarcoma protuberans | [1] | |||
Resistant Disease | Dermatofibrosarcoma protuberans [ICD-11: 2B53.0] | |||
Resistant Drug | Imatinib | |||
Molecule Alteration | Missense mutation | chr1:26190151G>T |
||
Experimental Note | Identified from the Human Clinical Data | |||
In Vitro Model | Dermatofibrosarcoma protuberans tissue | . | ||
Experiment for Molecule Alteration |
Sequencing assay | |||
Mechanism Description | This finding includes mutations in the CARD10, PPP1R39, SAFB2, and STARD9 genes. CARD10 is associated with the activation of the NK-kB signaling pathway and is known to have clinical implications in gastric cancer, colon cancer, and non-small cell lung cance. A potential role for changes in the PPP1R39 gene has also been suggested in the development of human cancers. Further, the SAFB2 gene product is involved in a variety of cellular process, such as cell growth, apoptosis, and stress response and is associated with breast tumorigenesis. In a recent in vitro study, the STARD9 gene product was shown to be associated with mitotic microtubule formation and cell division and might be a potential candidate target to extend the reach of cancer therapeutics. Among the studies mentioned above, Crone et al. demonstrated that targeting CARD10 by microRNA-146a inhibited NF-kB signaling pathway activation in gastric cancer cell lines via reduction of tumor-promoting cytokines and growth factors including PDGFRB. This study showed the possible association between CARD10 inhibition and decreased level of PDGFR and also implied CARD10 activating mutation may be one of the possible resistance mechanism to PBGFR inhibition by imatinib in DFSP. |
References
If you find any error in data or bug in web service, please kindly report it to Dr. Sun and Dr. Zhang.