Molecule Information
General Information of the Molecule (ID: Mol02086)
Name |
Glutathione S-transferase kappa (GST)
,H9N2 subtype
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Synonyms |
QR98_0015530
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Molecule Type |
Protein
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Gene Name |
GST
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Sequence |
MTVVEFFFDIISPYSRLQYELLMRKVPHWKSMQLKLTPVSIRAIFEGSSNPSPALNPVKR
AYLLRDLEMVHQYHDIPFAIPNDFMKIAIEIGSLKLQHFLAAIQSEIDDETFKRLVGEKF FDPNNPINVFLEDQFKQVAIDMKIDRNLIEKILSRLDSEEIKAKLEENNRIALNLGGFGL PITLVHCDPPQWVFGSDRMHLLAHLLHESI Click to Show/Hide
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Uniprot ID | |||||
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Type(s) of Resistant Mechanism of This Molecule
DISM: Drug Inactivation by Structure Modification
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
Ivermectin
Drug Resistance Data Categorized by Their Corresponding Mechanisms | ||||
Drug Inactivation by Structure Modification (DISM) | ||||
Disease Class: Scabies | [1] | |||
Resistant Disease | Scabies [ICD-11: 1G04.0] | |||
Resistant Drug | Ivermectin | |||
Molecule Alteration | Expression | Up-regulation |
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Experimental Note | Identified from the Human Clinical Data | |||
In Vitro Model | Sarcoptes scabiei isolates | 52283 | ||
Mechanism Description | The enzyme GST catalyzes the formation of a thioester bond between reduced glutathione and drugs. This bond tags the drug for elimination from the body. Increased activity or expression of GST has been linked to resistance to both permethrin and ivermectin in different mite species. |
References
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