General Information of the Molecule (ID: Mol02086)
Name
Glutathione S-transferase kappa (GST) ,H9N2 subtype
Synonyms
QR98_0015530
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Molecule Type
Protein
Gene Name
GST
Sequence
MTVVEFFFDIISPYSRLQYELLMRKVPHWKSMQLKLTPVSIRAIFEGSSNPSPALNPVKR
AYLLRDLEMVHQYHDIPFAIPNDFMKIAIEIGSLKLQHFLAAIQSEIDDETFKRLVGEKF
FDPNNPINVFLEDQFKQVAIDMKIDRNLIEKILSRLDSEEIKAKLEENNRIALNLGGFGL
PITLVHCDPPQWVFGSDRMHLLAHLLHESI
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Uniprot ID
A0A131ZWQ3_SARSC
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Sarcoptiformes
Family: Sarcoptidae
Genus: Sarcoptes
Species: H9N2 subtype
Type(s) of Resistant Mechanism of This Molecule
  DISM: Drug Inactivation by Structure Modification
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
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Ivermectin
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Drug Inactivation by Structure Modification (DISM) Click to Show/Hide
Disease Class: Scabies [1]
Resistant Disease Scabies [ICD-11: 1G04.0]
Resistant Drug Ivermectin
Molecule Alteration Expression
Up-regulation
Experimental Note Identified from the Human Clinical Data
In Vitro Model Sarcoptes scabiei isolates 52283
Mechanism Description The enzyme GST catalyzes the formation of a thioester bond between reduced glutathione and drugs. This bond tags the drug for elimination from the body. Increased activity or expression of GST has been linked to resistance to both permethrin and ivermectin in different mite species.
References
Ref 1 Scabies in the age of increasing drug resistance .PLoS Negl Trop Dis. 2017 Nov 30;11(11):e0005920. doi: 10.1371/journal.pntd.0005920. eCollection 2017 Nov. 10.1371/journal.pntd.0005920

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