Molecule Information

General Information of the Molecule (ID: Mol02019)

Name	ATP binding cassette subfamily G member 4 (ABCG4) ,Mycobacteroides abscessus
Synonyms	ABCG4; LPMP_150900 Click to Show/Hide
Molecule Type	Protein
Gene Name	ABCG4
Gene ID	22573510
Sequence	MGKQVDQVYNPSARTLTPPLRETSEQVALRNTPVDTTDALAMPPLSESDGKDTKVPTCSR AVNFTWENLTYQVPVEDKDGNVTYKTLLFNLSGCAKGGRVLAIMGPSGAGKTTLMGTITG KLYNATARQEGCCFMNNNIYQQRYKRLVSYVCQDDIVMGKDTPREAIFFSARLRLGLDSS TARRRTADVIKRLSLTRCQDTILGIPGILKGVSGGERKRTNIGTELITNPFVMLLDEPTT GLDSVNAVRVGQLLQDLAKNDMRTVIATVHSPSSELFDLFDDLLLLAKGHVIYHGPTADS IEYFASLGYDVPPRTNPTEYFMNLLQLPEDILSQLWLAWEDYVMSDAARYNPCLTPVTGA ITLTDDYLEEQLELKGASFCLQFSELFKRSWRMYLRDPGNFYGRSVQTLFFAIFLGLFFF NVQLNQQGVQDRQGALYMTLMNNLFGAAMNGIAAFPPERAVFLQEQANDAYNAYTYFLAK NAAELPWQILFPTLFDLIAYFLIHFHRSADAFFVHWFILVLLANLGYAFGLMFATFFKQS QAAFAMVPLILLPLFIVAGLFASTDRLYPYWVWLNYLSFPRHAYLGVFTNEFERLTVICS PVTPLCTFPDGQSVIEHMGFQNWRYWQSFIALIVYQIGLRFIGATSLFFQGRKRRGKLQF VKNLRHRVASPRAIASARSNDVLSDVQSTLVGSIATPSNAYGAETSLRDHQEPHHSLWGN EIELAALSPLDTPVTFEESPISVREKKHRY Click to Show/Hide
Uniprot ID	A0A088RLA3_9TRYP
HGNC ID	HGNC:13884
*Click to Show/Hide the Complete Species Lineage*
Kingdom: N.A. Phylum: Actinobacteria Class: Actinomycetia Order: Corynebacteriales Family: Mycobacteriaceae Genus: Mycobacteroides Species: Mycobacteroides abscessus

Type(s) of Resistant Mechanism of This Molecule

IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Miltefosine

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Disease Class: Leishmaniasis			[1]
Resistant Disease	Leishmaniasis [ICD-11: 1F54.1]		Disease Info
Resistant Drug	Miltefosine		Drug Info
Molecule Alteration	Expression	Down-regulation
Experimental Note	Discovered Using In-vivo Testing Model
Mechanism Description	In addition, the overexpression of ABC transporters ABCB4(MDR1), ABCG4, and ABCG6 has also been described to be associated with an increased resistance to several alkyl-lysophospholipids analogues, including MIL in Leishmania, due to a reduced intracellular accumulation because of increased efflux of the drug across the plasma membrane.

References

Ref 1	Drug resistance and treatment failure in leishmaniasis: A 21st century challenge .PLoS Negl Trop Dis. 2017 Dec 14;11(12):e0006052. doi: 10.1371/journal.pntd.0006052. eCollection 2017 Dec. 10.1371/journal.pntd.0006052