Molecule Information

General Information of the Molecule (ID: Mol02012)

• Name: multidrug resistance regulator 2 (MRR2) ,Candida albicans
• Synonyms: MRR2; ZCF34; CAALFM_C307860CA; CaO19.6182
• Molecule Type: Protein
• Gene Name: MRR2
• Gene ID: 3647468
• Sequence:
  MTKRDRTIYSCDACRSRKIKCNRQTPCASCHKSKRDCVYTVSRQRDAQITNRKLDKKTYH
  QISAIEKKISALEGKKGLLQVETINFNKSFTDQTPLVELQSLFPYLLLSKQDPGCVLVRH
  HCHHLLEKDPRYFEYSQLLADLSLTKRHHLTARAKALLGEAYIPSPQEGHTIDQLKHVLS
  LNPNFRFAGNFADPLTSFFSLIPPAWANKQLVDTFFQHIYPVIPIIDETDFNTSINRVLG
  PQIDGHYINSFPSIGSADDLPFLALFLLVLRISYMYTPGACPVSYDTLRAAETIMKEFDI
  TKTHSLTALQAEIMLRFYKIVAPESYTQSNYVQVSVGVLIQNCYSLALHRDPEYIGEHNP
  KQQHLRRKIWHLLLRMEVIDSAIFQTILSSNPDASDTKLPQLIDQAPPMEQSIVKHIWRS
  TDLFVSLRKLVEINSKTSEDTPLETVLELLVEVETKLQAFLATIDSEASTVFYNDLVIFS
  VNFLLVYMYYSLYLFKGPTPLGNKYLLKSAQILFVDLARTRSTSLFLAYFNLNYIHLVLM
  ITNFLRMRVDCIIHRHLRAQDSSVQDLQCCRYFLKIIFFSHVKELGNYSSSHKYAWQMRK
  VYLTLAKIMERSSDVLISNDPELVKSAAVDIPVKEINKLLEQYINFKGFTPTTLFDPTDN
  ELIDEMQHENLWNAMENIEYSEKVYSGWIDAIKNVPSNWDWDYWDFLKIS
• Function: Transcription factor that controls the expression of CDR1, the major multidrug efflux pump. Required for yeast cell adherence to silicone substrate and plays a role in virulence.
• Uniprot ID: MRR2_CANAL

Kingdom: Fungi
Phylum: Ascomycota
Class: Saccharomycetes
Order: Saccharomycetales
Family: Debaryomycetaceae
Genus: Candida
Species: Candida albicans

Type(s) of Resistant Mechanism of This Molecule

  IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Fluconazole

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Irregularity in Drug Uptake and Drug Efflux (IDUE)

Disease Class: Vulvovaginal candidiasis [1]

• Resistant Disease: Vulvovaginal candidiasis [ICD-11: 1F23.1]
• Resistant Drug: Fluconazole
• Molecule Alteration: Missense mutation; p.T83A
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Candida albicans isolates; 5476
• In Vitro Model: Candida albicans ATCC 11006; 5476
• In Vitro Model: Candida parapsilosis ATCC 22019; 5480
• In Vitro Model: Candida krusei ATCC 6258; 4909
• Experiment for Molecule Alteration: qRT-PCR
• Experiment for Drug Resistance: Broth dilution method assay
• Mechanism Description: Efflux pumps including Cdr1 also have been demonstrated as important molecular mechanisms responsible for fluconazole resistance by actively transporting the drug out of the cell.he Mrr2 gene mutation might cause fluconazole resistance through Cdr1 upregulation.

Disease Class: Vulvovaginal candidiasis [1]

• Resistant Disease: Vulvovaginal candidiasis [ICD-11: 1F23.1]
• Resistant Drug: Fluconazole
• Molecule Alteration: Missense mutation; p.T386I
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Candida albicans isolates; 5476
• In Vitro Model: Candida albicans ATCC 11006; 5476
• In Vitro Model: Candida parapsilosis ATCC 22019; 5480
• In Vitro Model: Candida krusei ATCC 6258; 4909
• Experiment for Molecule Alteration: qRT-PCR
• Experiment for Drug Resistance: Broth dilution method assay
• Mechanism Description: Efflux pumps including Cdr1 also have been demonstrated as important molecular mechanisms responsible for fluconazole resistance by actively transporting the drug out of the cell.he Mrr2 gene mutation might cause fluconazole resistance through Cdr1 upregulation.

Disease Class: Vulvovaginal candidiasis [1]

• Resistant Disease: Vulvovaginal candidiasis [ICD-11: 1F23.1]
• Resistant Drug: Fluconazole
• Molecule Alteration: Missense mutation; p.S466L
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Candida albicans isolates; 5476
• In Vitro Model: Candida albicans ATCC 11006; 5476
• In Vitro Model: Candida parapsilosis ATCC 22019; 5480
• In Vitro Model: Candida krusei ATCC 6258; 4909
• Experiment for Molecule Alteration: qRT-PCR
• Experiment for Drug Resistance: Broth dilution method assay
• Mechanism Description: Efflux pumps including Cdr1 also have been demonstrated as important molecular mechanisms responsible for fluconazole resistance by actively transporting the drug out of the cell.he Mrr2 gene mutation might cause fluconazole resistance through Cdr1 upregulation.

Disease Class: Vulvovaginal candidiasis [1]

• Resistant Disease: Vulvovaginal candidiasis [ICD-11: 1F23.1]
• Resistant Drug: Fluconazole
• Molecule Alteration: Missense mutation; p.H31Y
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Candida albicans isolates; 5476
• In Vitro Model: Candida albicans ATCC 11006; 5476
• In Vitro Model: Candida parapsilosis ATCC 22019; 5480
• In Vitro Model: Candida krusei ATCC 6258; 4909
• Experiment for Molecule Alteration: qRT-PCR
• Experiment for Drug Resistance: Broth dilution method assay
• Mechanism Description: Efflux pumps including Cdr1 also have been demonstrated as important molecular mechanisms responsible for fluconazole resistance by actively transporting the drug out of the cell.he Mrr2 gene mutation might cause fluconazole resistance through Cdr1 upregulation.

References

• Ref 1: Recurrent vulvovaginal candidiasis .Am J Obstet Gynecol. 2016 Jan;214(1):15-21. doi: 10.1016/j.ajog.2015.06.067. Epub 2015 Jul 9. 10.1016/j.ajog.2015.06.067