Molecule Information

General Information of the Molecule (ID: Mol01991)

• Name: Transcription factor PDR3 (PDR3) ,Saccharomyces cerevisiae
• Synonyms: PDR3; YBL005W; YBL0323
• Molecule Type: Protein
• Gene Name: PDR3
• Gene ID: 852278
• Sequence:
  MKVKKSTRSKVSTACVNCRKRKIKCTGKYPCTNCISYDCTCVFLKKHLPQKEDSSQSLPT
  TAVAPPSSHANVEASADVQHLDTAIKLDNQYYFKLMNDLIQTPVSPSATHAPDTSNNPTN
  DNNILFKDDSKYQNQLVTYQNILTNLYALPPCDDTQLLIDKTKSQLNNLINSWNPEINYP
  KLSSFSPRPQRSIETYLLTNKYRNKIHMTRFSFWTDQMVKSQSPDSFLATTPLVDEVFGL
  FSPIQAFSLRGIGYLIKKNIENTGSSMLIDTKETIYLILRLFDLCYEHLIQGCISISNPL
  ENYLQKIKQTPTTTASASLPTSPAPLSNDLVISVIHQLPQPFIQSITGFTTTQLIENLHD
  SFSMFRIVTQMYAQHRKRFAEFLNQAFSLPHQEKSVLFSSFCSSEYLLSTLCYAYYNVTL
  YHMLDINTLDYLEILVSLLEIQNEIDERFGFEKMLEVAVTCSTKMGLSRWEYYVGIDENT
  AERRRKIWWKIYSLEKRFLTDLGDLSLINEHQMNCLLPKDFRDMGFINHKEFLTKIGTSS
  LSPSSPKLKNLSLSRLIEYGELAIAQIVGDFFSETLYNEKFTSLEVSVKPTIIRQKLLEK
  VFEDIESFRLKLAKIKLHTSRVFQVAHCKYPEYPKNDLIEAAKFVSYHKNTWFSILGAVN
  NLIARLSEDPEVITEQSMKYANEMFQEWREINQFLIQVDTDFIVWACLDFYELIFFVMAS
  KFYVEDPHITLEDVINTLKVFKRITNIISFFNNNLDEKDYDCQTFREFSRSSSLVAISIR
  IIFLKYCYAEQIDRAEFIERLKEVEPGLSDLLREFFDTRSFIYRYMLKSVEKSGFHLIIR
  KMLESDYKFLYRDKLATGNIPDQGNSSQISQLYDSTAPSYNNASASAANSPLKLSSLLNS
  GEESYTQDASENVPCNLRHQDRSLQQTKRQHSAPSQISANENNIYNLGTLEEFVSSGDLT
  DLYHTLWNDNTSYPFL
• Function: PDR1 and PDR3 jointly control the transcription level of both SNQ2 and PDR5.
• Uniprot ID: PDR3_YEAST

Kingdom: Fungi
Phylum: Ascomycota
Class: Saccharomycetes
Order: 4892
Family: Saccharomycetaceae
Genus: Saccharomyces
Species: Saccharomyces cerevisiae

Type(s) of Resistant Mechanism of This Molecule

  UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Lovastatin

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms

Unusual Activation of Pro-survival Pathway (UAPP)

Disease Class: Fungal infection [1]

• Sensitive Disease: Fungal infection [ICD-11: 1F29-1F2F]
• Sensitive Drug: Lovastatin
• Molecule Alteration: Deletion mutation; Deleteion
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vitro Model: Saccharomyces cerevisiae strain Y12409; 4932
• In Vitro Model: Saccharomyces cerevisiae strain Y13029; 4932
• In Vitro Model: Saccharomyces cerevisiae strain Y13951; 4932
• In Vitro Model: Saccharomyces cerevisiae strain Y14381; 4932
• In Vitro Model: Sarcoma tissue; .
• Experiment for Molecule Alteration: PCR
• Experiment for Drug Resistance: Spot Test
• Mechanism Description: We investigated the susceptibility to lovastatin of S. cerevisiae strains deleted for PDR genes, responsible for exporting hydrophobic and amphiphilic drugs, such as lovastatin. Strains deleted for the genes tested, PDR1, PDR3, PDR5 and SNQ2, exhibited remarkably different phenotypes, with deletion of PDR5 causing the highest sensitivity to lovastatin. The study helped clarifying which pdr mutants to use in studies of physiological actions of statins in yeast.

References

• Ref 1: Sensitivity to lovastatin of Saccharomyces cerevisiae strains deleted for pleiotropic drug resistance (PDR) genes .J Mol Microbiol Biotechnol. 2011;20(4):191-5. doi: 10.1159/000329068. Epub 2011 Jul 12. 10.1159/000329068