Molecule Information

General Information of the Molecule (ID: Mol01879)

Name	Histamine receptor H1 (HRH1) ,Homo sapiens
Synonyms	HRH1 Click to Show/Hide
Molecule Type	Protein
Gene Name	HRH1
Gene ID	3269
Location	chr3:11,137,093-11,263,557[+]
Sequence	MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK RILHIRS Click to Show/Hide
Function	In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. Click to Show/Hide
Uniprot ID	HRH1_HUMAN
Ensembl ID	ENSG00000196639
HGNC ID	HGNC:5182
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Cloperastine

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Aberration of the Drug's Therapeutic Target (ADTT)			Click to Show/Hide
Disease Class: Cervical cancer				[1]
Sensitive Disease	Cervical cancer [ICD-11: 2C77.0]			Disease Info
Sensitive Drug	Cloperastine			Drug Info
Molecule Alteration	Function		Inhibition
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	SW480 cells	Colon	Homo sapiens (Human)	CVCL_0546
Experiment for Molecule Alteration	Quantitative RT-PCR assay
Experiment for Drug Resistance	CCK-8 assay; Flow cytometric analysis
Mechanism Description	Histamine H1 receptor antagonists selectively kill cisplatin-resistant human cancer cells. Here we show that cloperastine and two other histamine H1 receptor antagonists selectively kill HeLa cisR cells at concentrations that little affect parental HeLa S cells.

Disease- and Tissue-specific Abundances of This Molecule

ICD Disease Classification 02

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Cervical cancer [ICD-11: 2C77]

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Differential expression of molecule in resistant diseases
The Studied Tissue	Cervix uteri
The Specified Disease	Cervical cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.23E-01; Fold-change: 2.38E-01; Z-score: 5.47E-01
Molecule expression in the diseased tissue of patients Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances		Click to View the Clearer Original Diagram
Download Molecule expression barchart for all samples Download Molecule expression data of patients in the disease section of the tissue Download Molecule expression data in the tissue of healthy individual

Tissue-specific Molecule Abundances in Healthy Individuals

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Download the Tissue-Specific Variation(s) Profile

References

Ref 1	Histamine H1 receptor antagonists selectively kill cisplatin-resistant human cancer cells .Sci Rep. 2021 Jan 15;11(1):1492. doi: 10.1038/s41598-021-81077-y. 10.1038/s41598-021-81077-y