Molecule Information

General Information of the Molecule (ID: Mol01762)

• Name: hsa-miR-3182 ,Homo sapiens
• Synonyms: microRNA 3182
• Molecule Type: Mature miRNA
• Sequence: GCUUCUGUAGUGUAGUC
• Ensembl ID: ENSG00000263785
• HGNC ID: HGNC:38317
• Mature Accession: MIMAT0015062

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Doxorubicin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Osteosarcoma [1]

• Resistant Disease: Osteosarcoma [ICD-11: 2B51.0]
• Resistant Drug: Doxorubicin
• Molecule Alteration: Expression; Down-regulation
• Experimental Note: Identified from the Human Clinical Data
• Cell Pathway Regulation: ODRUL/miR3182/MMP2 signaling pathway; Regulation; hsa05206
• In Vitro Model: MG63 cells; Bone marrow; Homo sapiens (Human); CVCL_0426
• In Vitro Model: SAOS-2 cells; Bone marrow; Homo sapiens (Human); CVCL_0548
• In Vitro Model: U2OS cells; Bone; Homo sapiens (Human); CVCL_0042
• In Vitro Model: HOS cells; Bone; Homo sapiens (Human); CVCL_0312
• In Vitro Model: 143B cells; Bone; Homo sapiens (Human); CVCL_2270
• In Vivo Model: Nude mouse xenograft model; Mus musculus
• Experiment for Molecule Alteration: Dual Luciferase Reporter Assay; PCR
• Experiment for Drug Resistance: Wound Healing Assay; Colony Formation Assay; CCK8 Assay
• Mechanism Description: LncRNA ODRUL Contributes to Osteosarcoma Progression through the miR3182/MMP2 Axis. miR3182 expression and function are inversely correlated with ODRUL expression in vitro and in vivo, miR3182 negatively regulated the mRNA level and the protein level of MMP2 expression. ODRUL could directly interact with miR3182 and upregulate MMP2 expression via its competing endogenous RNA activity on miR3182 at the posttranscriptional level.

References

• Ref 1: LncRNA ODRUL Contributes to Osteosarcoma Progression through the miR-3182/MMP2 Axis. Mol Ther. 2017 Oct 4;25(10):2383-2393. doi: 10.1016/j.ymthe.2017.06.027. Epub 2017 Jul 5.