Molecule Information

General Information of the Molecule (ID: Mol01752)
Name
hsa-miR-1294 ,Homo sapiens
Synonyms
microRNA 1294
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Molecule Type
Mature miRNA
Sequence
UGUGAGGUUGGCAUUGUUGUCU
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Ensembl ID
ENSG00000221430
HGNC ID
HGNC:35287
Mature Accession
MIMAT0005884
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Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Type(s) of Resistant Mechanism of This Molecule
  RTDM: Regulation by the Disease Microenvironment
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
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Cisplatin
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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
       Regulation by the Disease Microenvironment (RTDM) Click to Show/Hide
Disease Class: Ovarian cancer [1]
Sensitive Disease Ovarian cancer [ICD-11: 2C73.0]
 Disease Info 
Sensitive Drug Cisplatin
 Drug Info 
Molecule Alteration Expression
Up-regulation
Experimental Note Revealed Based on the Cell Line Data
Cell Pathway Regulation Cell invasion Inhibition hsa05200
Cell migration Inhibition hsa04670
Cell proliferation Inhibition hsa05200
In Vitro Model SkOV3 cells Ovary Homo sapiens (Human) CVCL_0532
Experiment for
Molecule Alteration		 RT-PCR
Experiment for
Drug Resistance		 CCK8 assay
Mechanism Description Overexpression of miR-1294 ameliorated cisplatin-resistant OC malignancy via inhibiting IGF1R.
References
Ref 1 MiR-1294 confers cisplatin resistance in ovarian Cancer cells by targeting IGF1R. Biomed Pharmacother. 2018 Oct;106:1357-1363. doi: 10.1016/j.biopha.2018.07.059. Epub 2018 Jul 23.

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