Molecule Information

General Information of the Molecule (ID: Mol01624)
Name
hsa-miR-200a-3p ,Homo sapiens
Synonyms
microRNA 200a
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Molecule Type
Mature miRNA
Sequence
UAACACUGUCUGGUAACGAUGU
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Ensembl ID
ENSG00000207607
HGNC ID
HGNC:31578
Mature Accession
MIMAT0000682
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Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Type(s) of Resistant Mechanism of This Molecule
  EADR: Epigenetic Alteration of DNA, RNA or Protein
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
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Fluorouracil
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Disease Class: Hepatocellular carcinoma [1]
Resistant Disease Hepatocellular carcinoma [ICD-11: 2C12.2]
 Disease Info 
Resistant Drug Fluorouracil
 Drug Info 
Molecule Alteration Expression
Up-regulation
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model Hep3B cells Liver Homo sapiens (Human) CVCL_0326
Experiment for
Molecule Alteration		 RT-qPCR
Experiment for
Drug Resistance		 MTS assay; Flow cytometric analysis; Colony forming assay
Mechanism Description miR200a-3p enhances anti-cancer drug resistance by decreasing DUSP6 expression.
References
Ref 1 microRNA-200a-3p increases 5-fluorouracil resistance by regulating dual specificity phosphatase 6 expression. Exp Mol Med. 2017 May 12;49(5):e327. doi: 10.1038/emm.2017.33.

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