Molecule Information

General Information of the Molecule (ID: Mol01602)

Name	hsa-miR-142-5p ,Homo sapiens
Synonyms	microRNA 142 Click to Show/Hide
Molecule Type	Mature miRNA
Sequence	CAUAAAGUAGAAAGCACUACU Click to Show/Hide
Ensembl ID	ENSG00000284353
HGNC ID	HGNC:31529
Mature Accession	MIMAT0000433
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s)

2 drug(s) in total

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Cisplatin

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Ovarian cancer				[1]
Sensitive Disease	Ovarian cancer [ICD-11: 2C73.0]			Disease Info
Sensitive Drug	Cisplatin			Drug Info
Molecule Alteration	Expression		Up-regulation
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cell apoptosis		Activation	hsa04210
	Cell viability		Inhibition	hsa05200
In Vitro Model	SkOV3 cells	Ovary	Homo sapiens (Human)	CVCL_0532
	HEK293T cells	Kidney	Homo sapiens (Human)	CVCL_0063
	OVCAR3 cells	Ovary	Homo sapiens (Human)	CVCL_0465
Experiment for Molecule Alteration	qRT-PCR
Experiment for Drug Resistance	MTT assay; Flow cytometry assay
Mechanism Description	miR-142-5p decreases cisplatin IC50 in OVCAR3 and SkOV3 ovarian cancer cells via downregulating XIAP.

Gemcitabine

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Pancreatic cancer				[2]
Sensitive Disease	Pancreatic cancer [ICD-11: 2C10.3]			Disease Info
Sensitive Drug	Gemcitabine			Drug Info
Molecule Alteration	Expression		Up-regulation
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Capan-1 cells	Pancreas	Homo sapiens (Human)	CVCL_0237
	SUIT-2 cells	Pancreas	Homo sapiens (Human)	CVCL_3172
Experiment for Molecule Alteration	qRT-PCR
Experiment for Drug Resistance	Propidium iodide assay
Mechanism Description	High miR-142-5p expression was significantly associated with longer survival times in the gemcitabine group.

References

Ref 1	miR-142-5p enhances cisplatin-induced apoptosis in ovarian cancer cells by targeting multiple anti-apoptotic genes. Biochem Pharmacol. 2019 Mar;161:98-112. doi: 10.1016/j.bcp.2019.01.009. Epub 2019 Jan 11.
Ref 2	MicroRNA expression as a predictive marker for gemcitabine response after surgical resection of pancreatic cancer. Ann Surg Oncol. 2011 Aug;18(8):2381-7. doi: 10.1245/s10434-011-1602-x. Epub 2011 Feb 23.