Molecule Information
General Information of the Molecule (ID: Mol01543)
Name |
hsa-mir-3656
,Homo sapiens
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Synonyms |
microRNA 3656
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Molecule Type |
Precursor miRNA
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Sequence |
CUUUCGGCCAGCGGGACGGCAUCCGAGGUGGGCUAGGCUCGGGCCCGUGGCGGGUGCGGG
GGUGGGAGG Click to Show/Hide
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HGNC ID | |||||
Precursor Accession | |||||
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Type(s) of Resistant Mechanism of This Molecule
RTDM: Regulation by the Disease Microenvironment
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
Gemcitabine
Drug Sensitivity Data Categorized by Their Corresponding Mechanisms | ||||
Regulation by the Disease Microenvironment (RTDM) | ||||
Disease Class: Pancreatic cancer | [1] | |||
Sensitive Disease | Pancreatic cancer [ICD-11: 2C10.3] | |||
Sensitive Drug | Gemcitabine | |||
Molecule Alteration | Expression | Down-regulation |
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Experimental Note | Revealed Based on the Cell Line Data | |||
Cell Pathway Regulation | Epithelial mesenchymal transition signaling pathway | Activation | hsa01521 | |
In Vitro Model | BxPC-3 cells | Pancreas | Homo sapiens (Human) | CVCL_0186 |
PANC-1 cells | Pancreas | Homo sapiens (Human) | CVCL_0480 | |
Capan-2 cells | Pancreas | Homo sapiens (Human) | CVCL_0026 | |
AsPC-1 cells | Pancreas | Homo sapiens (Human) | CVCL_0152 | |
SW1990 cells | Pancreas | Homo sapiens (Human) | CVCL_1723 | |
HPDE6-C7 cells | Pancreas | Homo sapiens (Human) | CVCL_0P38 | |
HTERT-HPNE cells | Pancreas | Homo sapiens (Human) | CVCL_C466 | |
PATU8988 cells | Pancreas | Homo sapiens (Human) | CVCL_1846 | |
CFPAC1 cells | Pancreas | Homo sapiens (Human) | CVCL_1119 | |
HPAC cells | Pancreas | Homo sapiens (Human) | CVCL_3517 | |
In Vivo Model | Nude mouse xenograft model | Mus musculus | ||
Experiment for Molecule Alteration |
qPCR | |||
Experiment for Drug Resistance |
MTS assay | |||
Mechanism Description | miR3656 expression enhances the chemosensitivity of pancreatic cancer to gemcitabine through modulation of the RHOF/EMT axis. miR3656 could target RHOF, a member of the Rho subfamily of small GTPases, and regulate the EMT process, enforced EMT progression via TWIST1 overexpression compromised the chemotherapy-enhancing effects of miR3656. Reduced miR3656 expression levels activated the EMT pathway through upregulation of RHOF, eventually causing drug resistance. |
References
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