General Information of the Molecule (ID: Mol01517)
Name
hsa-mir-505 ,Homo sapiens
Synonyms
microRNA 505
    Click to Show/Hide
Molecule Type
Precursor miRNA
Gene Name
MIR505
Gene ID
574508
Location
chrX:139924148-139924231[-]
Sequence
GAUGCACCCAGUGGGGGAGCCAGGAAGUAUUGAUGUUUCUGCCAGUUUAGCGUCAACACU
UGCUGGUUUCCUCUCUGGAGCAUC
    Click to Show/Hide
Ensembl ID
ENSG00000207633
HGNC ID
HGNC:32140
Precursor Accession
MI0003190
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Type(s) of Resistant Mechanism of This Molecule
  EADR: Epigenetic Alteration of DNA, RNA or Protein
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
Click to Show/Hide the Full List of Drugs
Methotrexate
Click to Show/Hide
Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Disease Class: Colorectal cancer [1]
Resistant Disease Colorectal cancer [ICD-11: 2B91.1]
Resistant Drug Methotrexate
Molecule Alteration Expression
Up-regulation
Experimental Note Identified from the Human Clinical Data
Cell Pathway Regulation Cell invasion Activation hsa05200
Cell viability Activation hsa05200
In Vitro Model SW480 cells Colon Homo sapiens (Human) CVCL_0546
SW620 cells Colon Homo sapiens (Human) CVCL_0547
LS174T cells Colon Homo sapiens (Human) CVCL_1384
Experiment for
Molecule Alteration
qRT-PCR
Experiment for
Drug Resistance
MTT assay; Colony-forming assay; Transwell assay; Wound healing assay; Flow cytometry assay
Mechanism Description miR-505 advanced MTX-induced LS174T cells migration and invasiveness as well as depressed LS174T/MTX cell apoptosis through the down-regulation of RASSF8.
References
Ref 1 MiR-505 mediates methotrexate resistance in colorectal cancer by targeting RASSF8. J Pharm Pharmacol. 2018 Jul;70(7):937-951. doi: 10.1111/jphp.12913. Epub 2018 May 3.

If you find any error in data or bug in web service, please kindly report it to Dr. Sun and Dr. Zhang.