Molecule Information

General Information of the Molecule (ID: Mol01323)

• Name: NF-kappaB interacting LncRNA (NKILA) ,Homo sapiens
• Synonyms: NKILA
• Molecule Type: LncRNA
• Gene Name: KCNQ1-AS2, KvDMR1, KvLQT1-AS, LIT1, NCRNA00012
• Gene ID: 105416157
• Location: chr20:57710156-57712780[+]
• Ensembl ID: ENSG00000278709
• HGNC ID: HGNC:51599

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Baicalein

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Hepatocellular carcinoma [1]

• Sensitive Disease: Hepatocellular carcinoma [ICD-11: 2C12.2]
• Sensitive Drug: Baicalein
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• Cell Pathway Regulation: Cell apoptosis; Activation; hsa04210
• Cell Pathway Regulation: Cell invasion; Inhibition; hsa05200
• Cell Pathway Regulation: Cell viability; Inhibition; hsa05200
• Cell Pathway Regulation: NF-kappaB signaling pathway; Inhibition; hsa04064
• In Vitro Model: HepG2 cells; Liver; Homo sapiens (Human); CVCL_0027
• In Vitro Model: HCCLM3 cells; Liver; Homo sapiens (Human); CVCL_6832
• In Vitro Model: Hep3B cells; Liver; Homo sapiens (Human); CVCL_0326
• In Vitro Model: SMMC7721 cells; Uterus; Homo sapiens (Human); CVCL_0534
• In Vitro Model: QSG-7701 cells; Liver; Homo sapiens (Human); CVCL_6944
• In Vivo Model: Nude mouse xenograft model; Mus musculus
• Experiment for Molecule Alteration: qRT-PCR
• Experiment for Drug Resistance: Luminescent cell viability assay; TUNEL assay; Transwell assay
• Mechanism Description: NkILA inhibited IkBalpha phosphorylation and enhanced the inhibitory roles of baicalein on NF-kB signaling in HCC cells.

Disease- and Tissue-specific Abundances of This Molecule

ICD Disease Classification 02

Liver cancer [ICD-11: 2C12]

Differential expression of molecule in resistant diseases

• The Studied Tissue: Bile duct
• The Specified Disease: Cholangiocarcinoma
• The Expression Level of Disease Section Compare with the Healthy Individual Tissue: p-value: 6.89E-05; Fold-change: -1.33E+00
• The Studied Tissue: Liver
• The Specified Disease: Liver hepatocellular carcinoma
• The Expression Level of Disease Section Compare with the Healthy Individual Tissue: p-value: 3.65E-03; Fold-change: -2.52E-01

References

• Ref 1: Long noncoding RNA NKILA enhances the anti-cancer effects of baicalein in hepatocellular carcinoma via the regulation of NF-kB signaling. Chem Biol Interact. 2018 Apr 1;285:48-58. doi: 10.1016/j.cbi.2018.02.027. Epub 2018 Feb 23.