General Information of the Molecule (ID: Mol01314)
Name
Novel transcript, overlapping ACER2 (RP11-363E7.4) ,Homo sapiens
Synonyms
RP11-363E7.4
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Molecule Type
LncRNA
Gene Name
ALIEN, C20orf56, DEANR1, FALCOR, HCCDR1, NCRNA00261, TCONS_00027846, bA216C10.1, onco-lncRNA-17
Location
chr9:19453209-19455173[+]
Ensembl ID
ENSG00000260912
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Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Type(s) of Resistant Mechanism of This Molecule
  EADR: Epigenetic Alteration of DNA, RNA or Protein
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
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Cisplatin
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Disease Class: Hepatocellular carcinoma [1]
Resistant Disease Hepatocellular carcinoma [ICD-11: 2C12.2]
Resistant Drug Cisplatin
Molecule Alteration Expression
Up-regulation
Experimental Note Revealed Based on the Cell Line Data
Cell Pathway Regulation p53 signaling pathway Activation hsa04115
In Vitro Model HepG2 cells Liver Homo sapiens (Human) CVCL_0027
Experiment for
Molecule Alteration
qPCR
Experiment for
Drug Resistance
Flow cytometric analysis
Mechanism Description Cisplatin induces HepG2 cell cycle arrest through targeting specific long noncoding RNAs and the p53 signaling pathway, the LncRNAs RP11-134G8.8, RP11-363E7.4 and RP1-193H18.2, and their co-expression genes, which annotated into the p53 signaling pathway, could be potential targets for cisplatin treatment.
Disease- and Tissue-specific Abundances of This Molecule
ICD Disease Classification 02
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Liver cancer [ICD-11: 2C12]
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Differential expression of molecule in resistant diseases
The Studied Tissue Bile duct
The Specified Disease Cholangiocarcinoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 6.22E-02; Fold-change: -1.48E-01
Molecule expression in the diseased tissue of patients
Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances Click to View the Clearer Original Diagram
The Studied Tissue Liver
The Specified Disease Liver hepatocellular carcinoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 2.85E-12; Fold-change: 1.23E-01
Molecule expression in the diseased tissue of patients
Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances Click to View the Clearer Original Diagram
Tissue-specific Molecule Abundances in Healthy Individuals
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References
Ref 1 Cisplatin induces HepG2 cell cycle arrest through targeting specific long noncoding RNAs and the p53 signaling pathway. Oncol Lett. 2016 Dec;12(6):4605-4612. doi: 10.3892/ol.2016.5288. Epub 2016 Oct 18.

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