Molecule Information

General Information of the Molecule (ID: Mol01311)

Name	HIF1A antisense RNA 3 (HIF1A-AS3) ,Homo sapiens
Synonyms	HIF1A-AS3 Click to Show/Hide
Molecule Type	LncRNA
Gene Name	ROR, lincRNA-RoR, lincRNA-ST8SIA3
Gene ID	105370526
Location	chr14:61707564-61751099[-]
Ensembl ID	ENSG00000258667
HGNC ID	HGNC:54284
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Cisplatin

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Bladder cancer				[1]
Resistant Disease	Bladder cancer [ICD-11: 2C94.0]			Disease Info
Resistant Drug	Cisplatin			Drug Info
Molecule Alteration	Expression		Up-regulation
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	Cell apoptosis		Inhibition	hsa04210
In Vitro Model	5637 cells	Bladder	Homo sapiens (Human)	CVCL_0126
	T24 cells	Bladder	Homo sapiens (Human)	CVCL_0554
	SW780 cells	Bladder	Homo sapiens (Human)	CVCL_1728
Experiment for Molecule Alteration	qRT-PCR
Experiment for Drug Resistance	MTT assay; Flow cytometry assay
Mechanism Description	Upregulated HIF1A-AS2 hampers the p53 family proteins dependent apoptotic pathway to promote Cis resistance in bladder cancer.

Disease- and Tissue-specific Abundances of This Molecule

ICD Disease Classification 02

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Bladder cancer [ICD-11: 2C94]

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Differential expression of molecule in resistant diseases
The Studied Tissue	Bladder
The Specified Disease	Bladder urothelial carcinoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 6.28E-01; Fold-change: -6.62E-02
Molecule expression in the diseased tissue of patients Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances		Click to View the Clearer Original Diagram
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Tissue-specific Molecule Abundances in Healthy Individuals

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Download the Tissue-Specific Variation(s) Profile

References

Ref 1	The long noncoding RNA HIF1A-AS2 facilitates cisplatin resistance in bladder cancer. J Cell Biochem. 2019 Jan;120(1):243-252. doi: 10.1002/jcb.27327. Epub 2018 Sep 14.