Molecule Information

General Information of the Molecule (ID: Mol01302)
Name
TTC36 and KMT2A antisense RNA 1 (TTC36-AS1) ,Homo sapiens
Synonyms
TTC36-AS1
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Molecule Type
LncRNA
Gene Name
AGD1, linc-NeD125, lncRNA-N2
Gene ID
101929089
Location
chr11:118510273-118531094[-]
Ensembl ID
ENSG00000255435
HGNC ID
HGNC:55495
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Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Type(s) of Resistant Mechanism of This Molecule
  EADR: Epigenetic Alteration of DNA, RNA or Protein
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
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Paclitaxel
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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
       Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Disease Class: Breast cancer [1]
Sensitive Disease Breast cancer [ICD-11: 2C60.3]
 Disease Info 
Sensitive Drug Paclitaxel
 Drug Info 
Molecule Alteration Expression
Down-regulation
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model MCF-7/PR cells Breast Homo sapiens (Human) CVCL_0031
Experiment for
Molecule Alteration		 qRT-PCR
Experiment for
Drug Resistance		 Sulforhodamine B assay
Mechanism Description Down-regulation of LncRNA RP11-770J1.3 and TMEM25 enhanced the sensitivity of MCF-7/PR cells to paclitaxel, and inhibited the expression of MRP, BCRP and MDR1/P-gp.
References
Ref 1 [Effects of lncRNA RP11-770J1.3 and TMEM25 expression on paclitaxel resistance in human breast cancer cells]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2017 Jul 25;46(4):364-370. doi: 10.3785/j.issn.1008-9292.2017.08.04.

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