Molecule Information

General Information of the Molecule (ID: Mol01300)

• Name: SIRT1 regulating LncRNA tumor promoter (SIRLNT) ,Homo sapiens
• Synonyms: SIRLNT
• Molecule Type: LncRNA
• Gene Name: HOXA3as
• Gene ID: 112543493
• Location: chr8:40298697-40353133[-]
• Ensembl ID: ENSG00000253802
• HGNC ID: HGNC:53902

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  RTDM: Regulation by the Disease Microenvironment

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Fluorouracil

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Regulation by the Disease Microenvironment (RTDM)

Disease Class: Breast cancer [1]

• Resistant Disease: Breast cancer [ICD-11: 2C60.3]
• Resistant Drug: Fluorouracil
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• Cell Pathway Regulation: Cell metastasis; Activation; hsa05205
• Cell Pathway Regulation: Cell proliferation; Activation; hsa05200
• Cell Pathway Regulation: Chemoresistance; Activation; hsa05207
• Cell Pathway Regulation: miR4766-5p/SIRT1 signaling pathway; Regulation; hsa05206
• In Vitro Model: MCF-7 cells; Breast; Homo sapiens (Human); CVCL_0031
• In Vitro Model: MDA-MB-231 cells; Breast; Homo sapiens (Human); CVCL_0062
• In Vitro Model: MDA-MB-468 cells; Breast; Homo sapiens (Human); CVCL_0419
• In Vivo Model: Nude mouse xenograft model; Mus musculus
• Experiment for Molecule Alteration: qPCR; Microarray
• Experiment for Drug Resistance: MTT assay; PE Annexin V assay; TUNEL assay; Invasion assay
• Mechanism Description: The promotion of cell proliferation and metastasis, the acquisition of chemoresistance, and the increased expression of SIRT1 induced by LncRNA-PRLB overexpression could be partly abrogated by ectopic expression of miR-4766-5p.

References

• Ref 1: A novel long non-coding RNA-PRLB acts as a tumor promoter through regulating miR-4766-5p/SIRT1 axis in breast cancer. Cell Death Dis. 2018 May 1;9(5):563. doi: 10.1038/s41419-018-0582-1.