Molecule Information

General Information of the Molecule (ID: Mol01299)

Name	HOXA cluster antisense RNA 2 (HOXA-AS2) ,Homo sapiens
Synonyms	HOXA-AS2 Click to Show/Hide
Molecule Type	LncRNA
Gene Name	PCA1, PCAT-1, PiHL
Gene ID	285943
Location	chr7:27107777-27134302[+]
Ensembl ID	ENSG00000253552
HGNC ID	HGNC:43745
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s)

3 drug(s) in total

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Dexamethasone

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Acute lymphocytic leukemia				[1]
Resistant Disease	Acute lymphocytic leukemia [ICD-11: 2B33.0]			Disease Info
Resistant Drug	Dexamethasone			Drug Info
Molecule Alteration	Expression		Up-regulation
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cell apoptosis		Inhibition	hsa04210
	Cell proliferation		Activation	hsa05200
	EGFR/RAS/RAF/MEK/ERK signaling pathway		Activation	hsa01521
In Vitro Model	Jurkat cells	Pleural effusion	Homo sapiens (Human)	CVCL_0065
	CCRF-CEM cells	Pleural effusion	Homo sapiens (Human)	CVCL_0207
Experiment for Molecule Alteration	qRT-PCR
Experiment for Drug Resistance	CCK8 assay; Flow cytometry assay
Mechanism Description	TCF7L2 activated HOXA-AS2 decreased the glucocorticoid sensitivity in acute lymphoblastic leukemia through regulating HOXA3/EGFR/Ras/Raf/MEk/ERk pathway.

Doxorubicin

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Acute myeloid leukemia				[2]
Resistant Disease	Acute myeloid leukemia [ICD-11: 2A60.0]			Disease Info
Resistant Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Up-regulation
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	Cell apoptosis		Inhibition	hsa04210
	Cell proliferation		Activation	hsa05200
	miR520c-3p/S100A4 signaling pathway		Regulation	hsa05206
In Vitro Model	THP-1 cells	Blood	Homo sapiens (Human)	CVCL_0006
	U937 cells	Blood	Homo sapiens (Human)	CVCL_0007
In Vivo Model	Nude mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR
Experiment for Drug Resistance	CCK8 assay; Flow cytometry assay
Mechanism Description	HOXA-AS2 Can enhance S100A4 expression by suppressing miR-520c-3p expression to promote adriamycin resistance in acute myeloid leukemia through the miR-520c-3p /S100A4 pathway.

Prednisone

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Acute lymphocytic leukemia				[1]
Resistant Disease	Acute lymphocytic leukemia [ICD-11: 2B33.0]			Disease Info
Resistant Drug	Prednisone			Drug Info
Molecule Alteration	Expression		Up-regulation
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cell apoptosis		Inhibition	hsa04210
	Cell proliferation		Activation	hsa05200
	EGFR/RAS/RAF/MEK/ERK signaling pathway		Activation	hsa01521
In Vitro Model	Jurkat cells	Pleural effusion	Homo sapiens (Human)	CVCL_0065
	CCRF-CEM cells	Pleural effusion	Homo sapiens (Human)	CVCL_0207
Experiment for Molecule Alteration	qRT-PCR
Experiment for Drug Resistance	CCK8 assay; Flow cytometry assay
Mechanism Description	TCF7L2 activated HOXA-AS2 decreased the glucocorticoid sensitivity in acute lymphoblastic leukemia through regulating HOXA3/EGFR/Ras/Raf/MEk/ERk pathway.

References

Ref 1	TCF7L2 activated HOXA-AS2 decreased the glucocorticoid sensitivity in acute lymphoblastic leukemia through regulating HOXA3/EGFR/Ras/Raf/MEK/ERK pathway. Biomed Pharmacother. 2019 Jan;109:1640-1649. doi: 10.1016/j.biopha.2018.10.046. Epub 2018 Nov 16.
Ref 2	Knockdown of Long Noncoding RNA HOXA-AS2 Suppresses Chemoresistance of Acute Myeloid Leukemia via the miR-520c-3p/S100A4 Axis. Cell Physiol Biochem. 2018;51(2):886-896. doi: 10.1159/000495387. Epub 2018 Nov 22.