Molecule Information
General Information of the Molecule (ID: Mol01287)
| Name |
SOCS2 antisense RNA 1 (SOCS2-AS1)
,Homo sapiens
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| Synonyms |
SOCS2-AS1
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| Molecule Type |
LncRNA
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| Gene ID | |||||
| Location |
chr12:93542022-93571768[-]
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| Ensembl ID | |||||
| HGNC ID | |||||
| Click to Show/Hide the Complete Species Lineage | |||||
Type(s) of Resistant Mechanism of This Molecule
EADR: Epigenetic Alteration of DNA, RNA or Protein
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
Docetaxel
| Drug Resistance Data Categorized by Their Corresponding Mechanisms | ||||
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Epigenetic Alteration of DNA, RNA or Protein (EADR)
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| Disease Class: Prostate cancer | [1] | |||
| Resistant Disease | Prostate cancer [ICD-11: 2C82.0] | |||
| Resistant Drug | Docetaxel | |||
| Molecule Alteration | Expression | Up-regulation |
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| Experimental Note | Revealed Based on the Cell Line Data | |||
| Cell Pathway Regulation | Cell apoptosis | Inhibition | hsa04210 | |
| Cell proliferation | Activation | hsa05200 | ||
| In Vitro Model | LNCaP cells | Prostate | Homo sapiens (Human) | CVCL_0395 |
| VCaP cells | Prostate | Homo sapiens (Human) | CVCL_2235 | |
| LTAD cells | Prostate | Homo sapiens (Human) | N.A. | |
| Experiment for Molecule Alteration |
qPCR | |||
| Experiment for Drug Resistance |
TUNEL assay; MTS assay | |||
| Mechanism Description | Androgen-induced Long Noncoding RNA (LncRNA) SOCS2-AS1 Promotes Cell Growth and Inhibits Apoptosis in Prostate Cancer Cells.suppressor of cytokine signaling 2-antisense transcript 1 (SOCS2-AS1), the expression of which was higher in castration-resistant prostate cancer model cells.SOCS2-AS1 promoted castration-resistant and androgen-dependent cell growth. We found that SOCS2-AS1 knockdown up-regulated genes related to the apoptosis pathway, including tumor necrosis factor superfamily 10 (TNFSF10), and sensitized prostate cancer cells to docetaxel treatment. Moreover, we also demonstrated that SOCS2-AS1 promotes androgen signaling by modulating the epigenetic control for AR target genes including TNFSF10 These findings suggest that SOCS2-AS1 plays an important role in the development of castration-resistant prostate cancer by repressing apoptosis. | |||
Disease- and Tissue-specific Abundances of This Molecule
ICD Disease Classification 02
Prostate cancer [ICD-11: 2C82]
| Differential expression of molecule in resistant diseases | ||
| The Studied Tissue | Prostate | |
| The Specified Disease | Prostate adenocarcinoma | |
| The Expression Level of Disease Section Compare with the Healthy Individual Tissue | p-value: 4.69E-11; Fold-change: 6.21E-02 | |
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Molecule expression in the diseased tissue of patients
Molecule expression in the normal tissue of healthy individuals
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| Disease-specific Molecule Abundances |
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Click to View the Clearer Original Diagram |
Tissue-specific Molecule Abundances in Healthy Individuals
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References
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