Molecule Information

General Information of the Molecule (ID: Mol01273)

• Name: LncRNA sorafenib resistance in renal cell carcinoma associated (LNCSRLR) ,Homo sapiens
• Synonyms: LNCSRLR
• Molecule Type: LncRNA
• Gene Name: NCK1-AS1, SLC35G2-AS1
• Gene ID: 109729161
• Location: chr3:146066344-146069185[-]
• Ensembl ID: ENSG00000240032
• HGNC ID: HGNC:52753

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Sorafenib

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Renal cell carcinoma [1]

• Resistant Disease: Renal cell carcinoma [ICD-11: 2C90.0]
• Resistant Drug: Sorafenib
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Identified from the Human Clinical Data
• Cell Pathway Regulation: Sorafenib tolerance; Activation; hsa00983
• In Vitro Model: 786-O cells; Kidney; Homo sapiens (Human); CVCL_1051
• In Vitro Model: A498 cells; Kidney; Homo sapiens (Human); CVCL_1056
• In Vitro Model: Caki-2 cells; Kidney; Homo sapiens (Human); CVCL_0235
• In Vitro Model: OSRC-2 cells; Kidney; Homo sapiens (Human); CVCL_1626
• Experiment for Molecule Alteration: Microarray assay
• Experiment for Drug Resistance: CCK8 assay
• Mechanism Description: Long noncoding RNA-SRLR elicits intrinsic sorafenib resistance via evoking IL-6/STAT3 axis in renal cell carcinoma. LncRNA-SRLR directly binds to NF-kB and promotes IL-6 transcription, leading to the activation of STAT3 and the development of sorafenib tolerance.

Disease- and Tissue-specific Abundances of This Molecule

ICD Disease Classification 02

Kidney cancer [ICD-11: 2C90]

Differential expression of molecule in resistant diseases

• The Studied Tissue: Kidney
• The Specified Disease: Kidney clear cell carcinoma
• The Expression Level of Disease Section Compare with the Healthy Individual Tissue: p-value: 1.33E-28; Fold-change: -5.89E-01
• The Studied Tissue: Kidney
• The Specified Disease: Kidney papillary cell carcinoma
• The Expression Level of Disease Section Compare with the Healthy Individual Tissue: p-value: 2.26E-05; Fold-change: -1.94E-01

References

• Ref 1: Long noncoding RNA-SRLR elicits intrinsic sorafenib resistance via evoking IL-6/STAT3 axis in renal cell carcinoma. Oncogene. 2017 Apr 6;36(14):1965-1977. doi: 10.1038/onc.2016.356. Epub 2016 Nov 14.