Molecule Information

General Information of the Molecule (ID: Mol01268)

Name	NR2F1 antisense RNA 1 (NR2F1-AS1) ,Homo sapiens
Synonyms	NR2F1-AS1 Click to Show/Hide
Molecule Type	LncRNA
Gene Name	LINC01458, lncRNA-AC130710
Gene ID	441094
Location	chr5:93360779-93585649[-]
Ensembl ID	ENSG00000237187
HGNC ID	HGNC:48622
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

Click to Show/Hide the Full List of Drugs

Oxaliplatin

Click to Show/Hide

Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Hepatocellular carcinoma				[1]
Resistant Disease	Hepatocellular carcinoma [ICD-11: 2C12.2]			Disease Info
Resistant Drug	Oxaliplatin			Drug Info
Molecule Alteration	Expression		Up-regulation
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cell apoptosis		Inhibition	hsa04210
	Cell invasion		Activation	hsa05200
	Cell viability		Activation	hsa05200
	Epithelial mesenchymal transition signaling pathway		Activation	hsa01521
	NR2F1/AS1/miR363/ABCC1 signaling pathway		Regulation	hsa05206
In Vitro Model	Huh-7 cells	Liver	Homo sapiens (Human)	CVCL_0336
	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
In Vivo Model	Nude mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR
Experiment for Drug Resistance	CCK8 assay; Transwell assay
Mechanism Description	Both NR2F1-AS1 and ABCC1 were up-regulated in oxaliplatin-resistant HCC cells,and miR-363 expression was increased in Huh7/OXA and HepG2/OXA cells transfected with NR2F1-AS1 siRNA compared to empty vector-transfected cells.

Disease- and Tissue-specific Abundances of This Molecule

ICD Disease Classification 02

Click to Show/Hide the Resistance Disease of This Class

Liver cancer [ICD-11: 2C12]

Click to Show/Hide

Differential expression of molecule in resistant diseases
The Studied Tissue	Bile duct
The Specified Disease	Cholangiocarcinoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 9.17E-03; Fold-change: -2.36E-01
Molecule expression in the diseased tissue of patients Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances		Click to View the Clearer Original Diagram
Download Molecule expression barchart for all samples Download Molecule expression data of patients in the disease section of the tissue Download Molecule expression data in the tissue of healthy individual
The Studied Tissue	Liver
The Specified Disease	Liver hepatocellular carcinoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 4.55E-01; Fold-change: 1.46E-02
Molecule expression in the diseased tissue of patients Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances		Click to View the Clearer Original Diagram
Download Molecule expression barchart for all samples Download Molecule expression data of patients in the disease section of the tissue Download Molecule expression data in the tissue of healthy individual

Tissue-specific Molecule Abundances in Healthy Individuals

Click to Show/Hide the Molecule Abundances


Download the Tissue-Specific Variation(s) Profile

References

Ref 1	LncRNA NR2F1-AS1 regulates hepatocellular carcinoma oxaliplatin resistance by targeting ABCC1 via miR-363. J Cell Mol Med. 2018 Jun;22(6):3238-3245. doi: 10.1111/jcmm.13605. Epub 2018 Mar 30.