Molecule Information

General Information of the Molecule (ID: Mol01254)
Name
Long non-protein coding RNA, p53 induced transcript (LINC-PINT) ,Homo sapiens
Synonyms
LINC-PINT
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Molecule Type
LncRNA
Gene Name
TRPM2-AS1
Gene ID
378805
Location
chr7:130938963-131110176[-]
Ensembl ID
ENSG00000231721
HGNC ID
HGNC:26885
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Type(s) of Resistant Mechanism of This Molecule
  EADR: Epigenetic Alteration of DNA, RNA or Protein
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
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Cisplatin
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Disease Class: Laryngeal carcinoma [1]
Resistant Disease Laryngeal carcinoma [ICD-11: 2C23.0]
 Disease Info 
Resistant Drug Cisplatin
 Drug Info 
Molecule Alteration Expression
Down-regulation
Experimental Note Revealed Based on the Cell Line Data
Cell Pathway Regulation Cell apoptosis Inhibition hsa04210
Hedgehog signaling pathway Regulation hsa04340
In Vitro Model HEp-2 cells Skin Homo sapiens (Human) CVCL_1906
Experiment for
Molecule Alteration		 RT-PCR
Experiment for
Drug Resistance		 CCK8 assay; Colony formation assay; Flow cytometry assay
Mechanism Description Long noncoding RNA LINC-PINT regulates laryngeal carcinoma cell stemness and chemoresistance through miR-425-5p/PTCH1/SHH axis.
References
Ref 1 Long noncoding RNA LINC-PINT regulates laryngeal carcinoma cell stemness and chemoresistance through miR-425-5p/PTCH1/SHH axis. J Cell Physiol. 2019 Dec;234(12):23111-23122. doi: 10.1002/jcp.28874. Epub 2019 May 26.

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