Molecule Information

General Information of the Molecule (ID: Mol01219)

Name	ZNFX1 antisense RNA 1 (ZFAS1) ,Homo sapiens
Synonyms	ZFAS1 Click to Show/Hide
Molecule Type	LncRNA
Gene Name	AGD2, AK001796, LINC00978, MIR4435-1HG, MORRBID, lncRNA-AWPPH
Gene ID	441951
Location	chr20:49278178-49299600[+]
Ensembl ID	ENSG00000177410
HGNC ID	HGNC:33101
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

RTDM: Regulation by the Disease Microenvironment

Drug Resistance Data Categorized by Drug

Approved Drug(s)

2 drug(s) in total

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Cisplatin

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Regulation by the Disease Microenvironment (RTDM)			Click to Show/Hide
Disease Class: Gastric cancer				[1]
Sensitive Disease	Gastric cancer [ICD-11: 2B72.1]			Disease Info
Sensitive Drug	Cisplatin			Drug Info
Molecule Alteration	Expression		Down-regulation
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cell colony		Inhibition	hsa05200
	Cell invasion		Inhibition	hsa05200
	Cell viability		Inhibition	hsa05200
	Wnt/Beta-catenin signaling pathway		Inhibition	hsa04310
In Vitro Model	SGC7901 cells	Gastric	Homo sapiens (Human)	CVCL_0520
Experiment for Molecule Alteration	RT-PCR
Experiment for Drug Resistance	CCK8 assay; Transwell assay; Flow cytometry assay
Mechanism Description	Silencing of ZFAS1 augmented the sensitivity to cis-platinum or paclitaxel in gastric cancer cancer cells and silencing of ZFAS1-induced inhibition of malignancies was reversed by beta-catenin.

Paclitaxel

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Regulation by the Disease Microenvironment (RTDM)			Click to Show/Hide
Disease Class: Gastric cancer				[1]
Sensitive Disease	Gastric cancer [ICD-11: 2B72.1]			Disease Info
Sensitive Drug	Paclitaxel			Drug Info
Molecule Alteration	Expression		Down-regulation
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Wnt/Beta-catenin signaling pathway		Regulation	hsa04310
In Vitro Model	SGC7901 cells	Gastric	Homo sapiens (Human)	CVCL_0520
Experiment for Molecule Alteration	RT-PCR
Experiment for Drug Resistance	CCK8 assay; Transwell assay; Flow cytometry assay
Mechanism Description	Silencing of ZFAS1 augmented the sensitivity to cis-platinum or paclitaxel in gastric cancer cancer cells and silencing of ZFAS1-induced inhibition of malignancies was reversed by beta-catenin.

Disease- and Tissue-specific Abundances of This Molecule

ICD Disease Classification 02

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Gastric cancer [ICD-11: 2B72]

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Differential expression of molecule in resistant diseases
The Studied Tissue	Stomach
The Specified Disease	Stomach adenocarcinoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 8.40E-33; Fold-change: -5.37E-02
Molecule expression in the diseased tissue of patients Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances		Click to View the Clearer Original Diagram
Download Molecule expression barchart for all samples Download Molecule expression data of patients in the disease section of the tissue Download Molecule expression data in the tissue of healthy individual

Tissue-specific Molecule Abundances in Healthy Individuals

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Download the Tissue-Specific Variation(s) Profile

References

Ref 1	Silencing of lncRNA ZFAS1 inhibits malignancies by blocking Wnt/Beta-catenin signaling in gastric cancer cells. Biosci Biotechnol Biochem. 2018 Mar;82(3):456-465. doi: 10.1080/09168451.2018.1431518. Epub 2018 Feb 9.