General Information of the Molecule (ID: Mol01214)
Name
Long non-protein coding RNA 1116 (LINC01116) ,Homo sapiens
Synonyms
LINC01116
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Molecule Type
LncRNA
Gene Name
CCTalpha, CT, CTPCT, PCYT1
Gene ID
375295
Location
chr2:176611464-176637931[-]
Ensembl ID
ENSG00000163364
HGNC ID
HGNC:49259
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Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Type(s) of Resistant Mechanism of This Molecule
  EADR: Epigenetic Alteration of DNA, RNA or Protein
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
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Sulforaphane
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Disease Class: Prostate cancer [1]
Resistant Disease Prostate cancer [ICD-11: 2C82.0]
Resistant Drug Sulforaphane
Molecule Alteration Expression
Up-regulation
Experimental Note Revealed Based on the Cell Line Data
Cell Pathway Regulation Cell proliferation Activation hsa05200
In Vitro Model LNCaP cells Prostate Homo sapiens (Human) CVCL_0395
PC3 cells Prostate Homo sapiens (Human) CVCL_0035
Experiment for
Molecule Alteration
Sequencing assay; qRT-PCR
Experiment for
Drug Resistance
Cell proliferation assay
Mechanism Description Knockdown of LINC01116 with siRNA decreased proliferation of prostate cancer cells, and significantly upregulated several genes including GAPDH (regulates glycolysis), MAP1LC3B2 (autophagy) and H2AFY (chromatin structure) and LncRNA LINC01116 is upregulated in a human prostate cancer cell line, is decreased by SFN treatment, and promotes cell proliferation in a human cancer cell line.
Disease- and Tissue-specific Abundances of This Molecule
ICD Disease Classification 02
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Prostate cancer [ICD-11: 2C82]
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Differential expression of molecule in resistant diseases
The Studied Tissue Prostate
The Specified Disease Prostate adenocarcinoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 1.35E-31; Fold-change: 3.59E-01
Molecule expression in the diseased tissue of patients
Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances Click to View the Clearer Original Diagram
Tissue-specific Molecule Abundances in Healthy Individuals
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References
Ref 1 Long noncoding RNAs and sulforaphane: a target for chemoprevention and suppression of prostate cancer. J Nutr Biochem. 2017 Apr;42:72-83. doi: 10.1016/j.jnutbio.2017.01.001. Epub 2017 Jan 12.

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