Molecule Information
General Information of the Molecule (ID: Mol01211)
Name |
Transmembrane protein 25 (TMEM25)
,Homo sapiens
|
||||
---|---|---|---|---|---|
Synonyms |
TMEM25
Click to Show/Hide
|
||||
Molecule Type |
LncRNA
|
||||
Gene Name |
CARMQ1, CHRMQ1, VLDLRCH
|
||||
Gene ID | |||||
Location |
chr11:118531041-118547280[+]
|
||||
Ensembl ID | |||||
HGNC ID | |||||
Click to Show/Hide the Complete Species Lineage | |||||
Type(s) of Resistant Mechanism of This Molecule
EADR: Epigenetic Alteration of DNA, RNA or Protein
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
Paclitaxel
Drug Sensitivity Data Categorized by Their Corresponding Mechanisms | ||||
Epigenetic Alteration of DNA, RNA or Protein (EADR) | ||||
Disease Class: Breast cancer | [1] | |||
Sensitive Disease | Breast cancer [ICD-11: 2C60.3] | |||
Sensitive Drug | Paclitaxel | |||
Molecule Alteration | Expression | Down-regulation |
||
Experimental Note | Revealed Based on the Cell Line Data | |||
In Vitro Model | MCF-7/PR cells | Breast | Homo sapiens (Human) | CVCL_0031 |
Experiment for Molecule Alteration |
qRT-PCR | |||
Experiment for Drug Resistance |
Sulforhodamine B assay | |||
Mechanism Description | Down-regulation of LncRNA RP11-770J1.3 and TMEM25 enhanced the sensitivity of MCF-7/PR cells to paclitaxel, and inhibited the expression of MRP, BCRP and MDR1/P-gp. |
References
If you find any error in data or bug in web service, please kindly report it to Dr. Sun and Dr. Zhang.