Molecule Information

General Information of the Molecule (ID: Mol01163)

• Name: ATP-binding cassette sub-family B5 (ABCB5) ,Salmonella nanoparticle
• Molecule Type: Protein
• Gene Name: P-gp

Kingdom: N.A.
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Salmonella
Species: Salmonella enterica subsp. enterica serovar Typhimurium

Type(s) of Resistant Mechanism of This Molecule

  IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Doxorubicin

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms

Irregularity in Drug Uptake and Drug Efflux (IDUE)

Disease Class: Bladder cancer [1]

• Sensitive Disease: Bladder cancer [ICD-11: 2C94.0]
• Sensitive Drug: Doxorubicin
• Molecule Alteration: Expression; Down-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• Cell Pathway Regulation: Cell apoptosis; Activation; hsa04210
• Cell Pathway Regulation: Cell viability; Inhibition; hsa05200
• In Vitro Model: UM-UC-3 cells; Bladder; Homo sapiens (Human); CVCL_1783
• In Vitro Model: CT26 cells; Colon; Mus musculus (Mouse); CVCL_7254
• In Vitro Model: Salmonella enterica serovar Typhimurium SL1344; 216597
• In Vitro Model: Salmonella enterica serovar Typhimurium SL1344 detaSipA; 216597
• In Vitro Model: Salmonella enterica serovar Typhimurium SL1344 detaSipB; 216597
• In Vitro Model: Salmonella enterica serovar Typhimurium SL1344 detaSipC; 216597
• In Vitro Model: Salmonella enterica serovar Typhimurium SL1344 detaSopB; 216597
• In Vivo Model: BALB/c nude mice xenograft model; Mus musculus
• Experiment for Drug Resistance: MTS assay
• Mechanism Description: Mimicking the ability of Salmonella to reverse multidrug resistance, we constructed a gold nanoparticle system packaged with a SipA corona, and found this bacterial mimic not only accumulates in tumours but also reduces P-gp at a SipA dose significantly lower than free SipA. Moreover, the Salmonella nanoparticle mimic suppresses tumour growth with a concomitant reduction in P-gp when used with an existing chemotherapeutic drug (that is, doxorubicin).

Disease Class: Breast cancer [1]

• Sensitive Disease: Breast cancer [ICD-11: 2C60.3]
• Sensitive Drug: Doxorubicin
• Molecule Alteration: Expression; Down-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• Cell Pathway Regulation: Cell apoptosis; Activation; hsa04210
• Cell Pathway Regulation: Cell viability; Inhibition; hsa05200
• In Vitro Model: MCF-7 cells; Breast; Homo sapiens (Human); CVCL_0031
• In Vitro Model: CT26 cells; Colon; Mus musculus (Mouse); CVCL_7254
• In Vitro Model: Salmonella enterica serovar Typhimurium SL1344; 216597
• In Vitro Model: Salmonella enterica serovar Typhimurium SL1344 detaSipA; 216597
• In Vitro Model: Salmonella enterica serovar Typhimurium SL1344 detaSipB; 216597
• In Vitro Model: Salmonella enterica serovar Typhimurium SL1344 detaSipC; 216597
• In Vitro Model: Salmonella enterica serovar Typhimurium SL1344 detaSopB; 216597
• In Vivo Model: BALB/c nude mice xenograft model; Mus musculus
• Experiment for Drug Resistance: MTS assay
• Mechanism Description: Mimicking the ability of Salmonella to reverse multidrug resistance, we constructed a gold nanoparticle system packaged with a SipA corona, and found this bacterial mimic not only accumulates in tumours but also reduces P-gp at a SipA dose significantly lower than free SipA. Moreover, the Salmonella nanoparticle mimic suppresses tumour growth with a concomitant reduction in P-gp when used with an existing chemotherapeutic drug (that is, doxorubicin).

Disease Class: Colorectal carcinoma [1]

• Sensitive Disease: Colorectal carcinoma [ICD-11: 2B91.3]
• Sensitive Drug: Doxorubicin
• Molecule Alteration: Expression; Down-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• Cell Pathway Regulation: Cell apoptosis; Activation; hsa04210
• Cell Pathway Regulation: Cell viability; Inhibition; hsa05200
• In Vitro Model: HCT8 cells; Colon; Homo sapiens (Human); CVCL_2478
• In Vitro Model: CT26 cells; Colon; Mus musculus (Mouse); CVCL_7254
• In Vitro Model: Salmonella enterica serovar Typhimurium SL1344; 216597
• In Vitro Model: Salmonella enterica serovar Typhimurium SL1344 detaSipA; 216597
• In Vitro Model: Salmonella enterica serovar Typhimurium SL1344 detaSipB; 216597
• In Vitro Model: Salmonella enterica serovar Typhimurium SL1344 detaSipC; 216597
• In Vitro Model: Salmonella enterica serovar Typhimurium SL1344 detaSopB; 216597
• In Vivo Model: BALB/c mice xenograft model; Mus musculus
• Experiment for Drug Resistance: MTS assay
• Mechanism Description: Mimicking the ability of Salmonella to reverse multidrug resistance, we constructed a gold nanoparticle system packaged with a SipA corona, and found this bacterial mimic not only accumulates in tumours but also reduces P-gp at a SipA dose significantly lower than free SipA. Moreover, the Salmonella nanoparticle mimic suppresses tumour growth with a concomitant reduction in P-gp when used with an existing chemotherapeutic drug (that is, doxorubicin).

References

• Ref 1: A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours. Nat Commun. 2016 Jul 25;7:12225. doi: 10.1038/ncomms12225.