Molecule Information
General Information of the Molecule (ID: Mol01162)
Name |
ATP-binding cassette sub-family B5 (ABCB5)
,Pichia pastoris
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Molecule Type |
Protein
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Gene Name |
P-gp
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Click to Show/Hide the Complete Species Lineage | |||||
Type(s) of Resistant Mechanism of This Molecule
IDUE: Irregularity in Drug Uptake and Drug Efflux
Drug Resistance Data Categorized by Drug
Approved Drug(s)
2 drug(s) in total
Loperamide
Drug Sensitivity Data Categorized by Their Corresponding Mechanisms | ||||
Irregularity in Drug Uptake and Drug Efflux (IDUE) | ||||
Disease Class: Pain | [1] | |||
Sensitive Disease | Pain [ICD-11: MG30.0] | |||
Sensitive Drug | Loperamide | |||
Molecule Alteration | Expression | Down-regulation |
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Experimental Note | Revealed Based on the Cell Line Data | |||
Experiment for Molecule Alteration |
ATPase activity assay | |||
Mechanism Description | P-glycoprotein (Pgp) is a multidrug resistance transporter that limits the penetration of a wide range of neurotherapeutics into the brain including opioids. Pgp-knockout mice had more than a 10-fold higher level of loperamide in their brains than wild-type. Both rats and humans have shown elevated levels of loperamide in the presence of the Pgp-specific inhibitor cyclosporine A. |
Methadone
Drug Sensitivity Data Categorized by Their Corresponding Mechanisms | ||||
Irregularity in Drug Uptake and Drug Efflux (IDUE) | ||||
Disease Class: Pain | [1] | |||
Sensitive Disease | Pain [ICD-11: MG30.0] | |||
Sensitive Drug | Methadone | |||
Molecule Alteration | Expression | Down-regulation |
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Experimental Note | Revealed Based on the Cell Line Data | |||
Experiment for Molecule Alteration |
ATPase activity assay | |||
Mechanism Description | P-glycoprotein (Pgp) is a multidrug resistance transporter that limits the penetration of a wide range of neurotherapeutics into the brain including opioids. Pgp-knockout mice had more than a 10-fold higher level of loperamide in their brains than wild-type. Both rats and humans have shown elevated levels of loperamide in the presence of the Pgp-specific inhibitor cyclosporine A. |
References
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