Molecule Information

General Information of the Molecule (ID: Mol01156)

• Name: t(17;17)(q21;q21) (Unclear) ,Homo sapiens
• Molecule Type: Protein
• Gene Name: t(17;17)(q21;q21)

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Tretinoin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Unusual Activation of Pro-survival Pathway (UAPP)

Disease Class: Acute myeloid leukemia [1]

• Resistant Disease: Acute myeloid leukemia [ICD-11: 2A60.0]
• Resistant Drug: Tretinoin
• Molecule Alteration: Structural mutation; Structural variation
• Experimental Note: Identified from the Human Clinical Data
• Cell Pathway Regulation: AKT/PI3 signaling pathway; Activation; hsa04151
• Cell Pathway Regulation: MAPK signaling pathway; Activation; hsa04010
• Cell Pathway Regulation: STAT signaling pathway; Activation; hsa04630
• Experiment for Molecule Alteration: Next-generation sequencing assay
• Mechanism Description: However, rarer variant translocations such as t(11;17)(q23;q21); ZBTB16-RARA or t(17;17)(q21;q21); STAT5B-RARA may result in resistance to ATRA.

References

• Ref 1: The diagnostic and clinical impact of genetics and epigenetics in acute myeloid leukemia. Int J Lab Hematol. 2015 May;37 Suppl 1:122-32. doi: 10.1111/ijlh.12367.