Molecule Information

General Information of the Molecule (ID: Mol01138)

Name	STAT5B-RARA fusion protein (STAT5B-RARA) ,Homo sapiens
Molecule Type	Protein
Gene Name	STAT5B-RARA
Gene ID	6777; 5914
Uniprot ID	STA5B_HUMAN/ RARA_HUMAN
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Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Tretinoin

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Aberration of the Drug's Therapeutic Target (ADTT)		Click to Show/Hide
Disease Class: Acute myeloid leukemia			[1]
Resistant Disease	Acute myeloid leukemia [ICD-11: 2A60.0]		Disease Info
Resistant Drug	Tretinoin		Drug Info
Molecule Alteration	Structural mutation	Structural variation
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	AKT/PI3 signaling pathway	Activation	hsa04151
	MAPK signaling pathway	Activation	hsa04010
	STAT signaling pathway	Activation	hsa04630
Experiment for Molecule Alteration	Next-generation sequencing assay
Mechanism Description	However, rarer variant translocations such as t(11;17)(q23;q21); ZBTB16-RARA or t(17;17)(q21;q21); STAT5B-RARA may result in resistance to ATRA.

References

Ref 1	The diagnostic and clinical impact of genetics and epigenetics in acute myeloid leukemia. Int J Lab Hematol. 2015 May;37 Suppl 1:122-32. doi: 10.1111/ijlh.12367.

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