Molecule Information

General Information of the Molecule (ID: Mol01086)

Name	Spectinomycin 9-O-adenylyltransferase (ANT9) ,Staphylococcus aureus
Synonyms	ant9; spd; SAMEA70245418_02659; EC 2.7.7.47; Spectinomycin adenyltransferase Click to Show/Hide
Molecule Type	Protein
Gene Name	ant9
Sequence	MEEPNKQIDNVLIELKRLFSKDLLGVYLYGSYVKGGLKKDSDVDFLVIINRDMTKEEKRI LISKIMPISKEIGEDTSLKYIELTVLNYHENENWSYPPIEEFIYGEWLREDYLNYFIPEK NNNIDLTILLYQAKLSSISIYGENNINNLIPDVPFIDLQKAIKESSKELIKDFYGDETNV ILTLCRMIVTYETGKFYSKDLAGSMIIENLSENLSIEENNLISLAISSYKNGNSVDWELF PVKSVIKKLYAYLNYKL Click to Show/Hide
Uniprot ID	W1JB67_STAAU
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Kingdom: N.A. Phylum: Firmicutes Class: Bacilli Order: Bacillales Family: Staphylococcaceae Genus: Staphylococcus Species: Staphylococcus aureus

Type(s) of Resistant Mechanism of This Molecule

DISM: Drug Inactivation by Structure Modification

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Spectinomycin

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Drug Inactivation by Structure Modification (DISM)		Click to Show/Hide
Disease Class: Bacterial infection			[1]
Resistant Disease	Bacterial infection [ICD-11: 1A00-1C4Z]		Disease Info
Resistant Drug	Spectinomycin		Drug Info
Molecule Alteration	Expression	Up-regulation
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Staphylococcus aureus ST398		523796
Experiment for Molecule Alteration	Whole genome sequence assay
Mechanism Description	Downstream of the repN sequence was located a novel spectinomycin adenyltransferase gene, which was designated spd. The gene encoded a novel 257 amino acid protein, named Spd, which shared 47% identity with the spectinomycin adenyltransferase Aad9 from Enterococcus faecalis.

References

Ref 1	Identification of a novel plasmid-associated spectinomycin adenyltransferase gene spd in methicillin-resistant Staphylococcus aureus ST398 isolated from animal and human sources. J Antimicrob Chemother. 2014 May;69(5):1193-6. doi: 10.1093/jac/dkt510. Epub 2014 Jan 8.