Molecule Information

General Information of the Molecule (ID: Mol01061)

Name	Pyruvate dehydrogenase E1 component subunit alpha (PDHA1) ,Mus musculus
Synonyms	PDHE1-A type I; Pdha-1 Click to Show/Hide
Molecule Type	Protein
Gene Name	Pdha1
Gene ID	18597
Location	chr X: 158905205-158921409[-]
Sequence	MRKMLAAVSRVLAGSAQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTRED GLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRA HGFTFTRGLPVRAILAELTGRRGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALA CKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAAST DYYKRGDFIPGLRVDGMDILCVREATKFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVS YRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPP LEELGYHIYSSDPPFEVRGANQWIKFKSVS Click to Show/Hide
Function	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. Click to Show/Hide
Uniprot ID	ODPA_MOUSE
Ensembl ID	ENSMUSG00000031299
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Rodentia Family: Muridae Genus: Mus Species: Mus musculus

Type(s) of Resistant Mechanism of This Molecule

RTDM: Regulation by the Disease Microenvironment

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

Click to Show/Hide the Full List of Drugs

Cetuximab

Click to Show/Hide

Drug Resistance Data Categorized by Their Corresponding Mechanisms
Regulation by the Disease Microenvironment (RTDM)			Click to Show/Hide
Disease Class: Colorectal cancer				[1]
Resistant Disease	Colorectal cancer [ICD-11: 2B91.1]			Disease Info
Resistant Drug	Cetuximab			Drug Info
Molecule Alteration	Expression		Down-regulation
Experimental Note	Discovered Using In-vivo Testing Model
Cell Pathway Regulation	Pentose phosphate signaling pathway		Activation	hsa00030
In Vitro Model	SW480 cells	Colon	Homo sapiens (Human)	CVCL_0546
	GEO cells	Colon	Homo sapiens (Human)	CVCL_0271
In Vivo Model	Xenografts mouse model			Mus musculus
Experiment for Molecule Alteration	2D DIGE assay
Mechanism Description	LDHB and PDHA1 were downregulated in GEO-CR tumor xenografts, similarly to the corresponding deregulations observed in the derived cell lines. Upregulation of G6PDH and transketolase (TkT) was also actually maintained in tumor xenografts. Indeed, PPP2CA expression in xenografted samples was similarly evaluated, demonstrating that protein downregulation in vivo was even more pronounced than that measured in GEO-CR cells.

References

Ref 1	Increased anaerobic metabolism is a distinctive signature in a colorectal cancer cellular model of resistance to antiepidermal growth factor receptor antibody. Proteomics. 2013 Mar;13(5):866-77. doi: 10.1002/pmic.201200303. Epub 2013 Jan 24.