Molecule Information

General Information of the Molecule (ID: Mol01046)

Name	Phospholipid-translocating ATPase (RTA2) ,Candida albicans
Synonyms	RTA2; orf19.24; CAALFM_C206470WA; Phospholipid-translocating ATPase Click to Show/Hide
Molecule Type	Protein
Gene Name	RTA2
Gene ID	3646567
Sequence	MSEILNYLSSWTPTSTPTSTTLSSIATSHVSKLSQTVASVISQATTETDWYNLRSLSQAY RGAQASLTIISAEKVLATATDSQVQSRATQAIFEATLNLKDLSMEQNIYGYELNRAANII YLVVYAIIFGYTLLMCIKSKYWWYNVTFVCGYGLEFVGFLGRVLSFNDTSNMSHYIMQSV ALTIAPAFIMAGVYFLFGQLVVIHGRQYSVLKPMWYSYFFITADVVSLLIQAAGGGIASV ASSNHKDSSVGTNIMIAGIAAQVVAMTIFLVFWFEFLNRLYFKNSRSDLIVDCPYGRRSI SNYFKLLLNVKSVRGHRHTHLEKYYNEKFASIRQIPLFDYMVLAMTIAVIVVYIRCVYRV AELAEGWGGYLFTHEPYLMILDAAMIAIAGLIFIPFHPVWVFGKNNIVKLATIKKNLDEN EKNQDVEYNDDVESQERSSSVVANDIHCLNSKL Click to Show/Hide
Uniprot ID	Q59Q40_CANAL
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Fungi Phylum: Ascomycota Class: Saccharomycetes Order: Saccharomycetales Family: Debaryomycetaceae Genus: Candida Species: Candida albicans

Type(s) of Resistant Mechanism of This Molecule

IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Fluconazole

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Disease Class: Candida albicans infection			[1]
Sensitive Disease	Candida albicans infection [ICD-11: 1F23.Y]		Disease Info
Sensitive Drug	Fluconazole		Drug Info
Molecule Alteration	Missense mutation	p.G234S
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	Calcineurin signaling pathway	Regulation	hsa04310
In Vitro Model	Candida albicans strain		5476
In Vivo Model	Systemic mice candidiasis model		Mus musculus
Experiment for Molecule Alteration	DNA sequencing assay
Experiment for Drug Resistance	Broth microdilution method assay
Mechanism Description	Furthermore, we confirmed that G234S mutant enhanced the therapeutic efficacy of fluconazole against systemic candidiasis and significantly increased the accumulation of dihydrosphingosine by decreasing its release.

References

Ref 1	Mutation of G234 amino acid residue in candida albicans drug-resistance-related protein Rta2p is associated with fluconazole resistance and dihydrosphingosine transport. Virulence. 2015;6(6):599-607. doi: 10.1080/21505594.2015.1051296.