Molecule Information

General Information of the Molecule (ID: Mol01042)

• Name: Phosphatidate cytidylyltransferase (CDSA) ,Streptococcus mitis
• Synonyms: B7703_01220; FOB92_07930; GEZ84_01335; RN80_03115; SMNM65_03110
• Molecule Type: Protein
• Gene Name: cdsA
• Sequence:
  MTQDLQKRTLFAGIALAIFLPILMIGGLLLQIAIGIIAMLAMHELLKMRGLETMTMEGLL
  TLFATFALTIPLENYLTFLPVDGNVVAYSVLISIMLGTTVFSKSYTIEDAVFPLAMSFYV
  GFGFNALLDARVAGLDKALLALCIVWATDSGAYLVGMNYGKRKLAPTVSPNKTFEGALGG
  ILGAILVTIIFMIVDSTVALPYGIYKMSVFAIFFSIAGQFGDLLESSIKRHFGVKDSGKF
  IPGHGGVLDRFDSMLLVFPIMHLFGLF
• Uniprot ID: A0A0M4KGJ3_STRMT

Kingdom: N.A.
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Species: Streptococcus mitis

Type(s) of Resistant Mechanism of This Molecule

  UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Daptomycin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Unusual Activation of Pro-survival Pathway (UAPP)

Disease Class: Streptococcus mitis/oralis infection [1]

• Resistant Disease: Streptococcus mitis/oralis infection [ICD-11: 1A00-1C4Z]
• Resistant Drug: Daptomycin
• Molecule Alteration: Missense mutation; p.D222N
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vitro Model: Streptococcus mitis isolates; 28037
• In Vitro Model: Streptococcus oralis isolates; 1303
• Experiment for Molecule Alteration: PCR; DNA sequence assay
• Mechanism Description: Mutation changes in CdsA cause daptomycin resistance in S. mitis/oralis.

References

• Ref 1: Perturbations of Phosphatidate Cytidylyltransferase (CdsA) Mediate Daptomycin Resistance in Streptococcus mitis/oralis by a Novel Mechanism. Antimicrob Agents Chemother. 2017 Mar 24;61(4):e02435-16. doi: 10.1128/AAC.02435-16. Print 2017 Apr.