Molecule Information

General Information of the Molecule (ID: Mol01020)

• Name: Na+/H+ exchanger-1 (PFNHE1) ,Plasmodium falciparum
• Synonyms: Pfnhe-1; Fragment
• Molecule Type: Protein
• Gene Name: Pfnhe-1
• Sequence:
  KKKKISGSNNDNNDNNNDDNNNDNNNNDNHNDDKNNKNDDDNHNDNHNNDDDNNNDNHND
  DDNNSSHYNKEKEANFNEYLTYQNLFALQNEDNNIINFFSNDKK
• Uniprot ID: C9EIA2_PLAFA

Kingdom: N.A.
Phylum: Apicomplexa
Class: Aconoidasida
Order: Haemosporida
Family: Plasmodiidae
Genus: Plasmodium
Species: Plasmodium falciparum

Type(s) of Resistant Mechanism of This Molecule

  IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Quinine

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Irregularity in Drug Uptake and Drug Efflux (IDUE)

Disease Class: Malaria [1]

• Resistant Disease: Malaria [ICD-11: 1F45.0]
• Resistant Drug: Quinine
• Molecule Alteration: Missense mutation + Chromosome variation; ms4760+ 3 DNNND repeats
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vitro Model: Plasmodium falciparum strains; 5833
• Experiment for Molecule Alteration: Genotypic characterization assay
• Experiment for Drug Resistance: SYBR Green I detection assay
• Mechanism Description: Eighty-two percent of parasites resistant to quinine carried mutant alleles at these codons (Pfmdr1-86Y, Pfmdr1-184F, and Pfcrt-76T), whereas 74% of parasites susceptible to quinine carried the wild-type allele (Pfmdr1-N86, Pfmdr1-Y184, and Pfcrt-k76, respect.

References

• Ref 1: Polymorphisms in Pfmdr1, Pfcrt, and Pfnhe1 genes are associated with reduced in vitro activities of quinine in Plasmodium falciparum isolates from western Kenya. Antimicrob Agents Chemother. 2014 Jul;58(7):3737-43. doi: 10.1128/AAC.02472-14. Epub 2014 Apr 21.