Molecule Information

General Information of the Molecule (ID: Mol00997)

Name	Major facilitator superfamily multidrug transporter FLU1 (FLU1) ,Candida albicans
Synonyms	Fluconazole resistance protein 1; CAALFM_C701520WA; orf19.6577 Click to Show/Hide
Molecule Type	Protein
Gene Name	FLU1
Gene ID	3637048
Sequence	MNNNTNSNHNDIAPEATITQNTTTSVSNDELQHITNNNNVNVQSYVGPTDSVESSSNTAD EENEINSFNAQNVKDYEANVGGELPPDDELSRIESNTELSRRATRSIMNTESLLRTASQS SKPLPPMGGGKEYPPMLGSRDPYVVAFDGPDDPDHPHNYPTWKKILYCASVGLAALSVSM GSAMFSQASADIMQIYHIGWTPATLTTSLFVFGFASGPVIYGPLSELFGRKLVMVPSCLG YVCFSFAVATAKDIQTIMICRFFAGFIGAAPLVVAPAVMADMFNNRYRGTAIAIFSMLLF GGPMLAPILGAFTVKNSALGWRWTSYFCGIIGSLALFMNTFLLQETHHPLILTRRAEELR RRTGNWGIYAPHEELKLSMKEIVENNIARPLKMLFTEPILFLVSLYNAFIYGMLYLFLTA IPLIFLGEYHFVQGVAELPYLAMLIGILIGGGMIMLFEKRYIKAMEDNGGKIIPEKRLEP MMVGGFTFVIGIFWLGWTGNYPQHVHWIVPVIGAAFVGNGLMLIFLPCFNYIIDCYLLYA ATALAGNTFIRSAFGAVFPLFARQMFTNLTIKWASTLLGCIGILLLPMPFVFYYYGKSLR HKSKFAFVLE Click to Show/Hide
Function	Major facilitator superfamily transporter that mediates resistance to structurally and functionally unrelated compounds including cycloheximide but also azoles such as fuconazole, ketoconazole and itraconazole. Mediates also efflux of histatin 5, a salivary human antimicrobial peptide, and is responsible for reduction of its toxicity in C.albicans. Click to Show/Hide
Uniprot ID	FLU1_CANAL
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Fungi Phylum: Ascomycota Class: Saccharomycetes Order: Saccharomycetales Family: Debaryomycetaceae Genus: Candida Species: Candida albicans

Type(s) of Resistant Mechanism of This Molecule

IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Fluconazole

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Disease Class: Candidosis			[1]
Resistant Disease	Candidosis [ICD-11: 1F23.0]		Disease Info
Resistant Drug	Fluconazole		Drug Info
Molecule Alteration	Expression	Up-regulation
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	South America Candida albicans strain		5476
Experiment for Molecule Alteration	RT-PCR
Experiment for Drug Resistance	Broth microdilution method assay
Mechanism Description	Overexpression of the genes ERG11, CDR1, CDR2, MDR1, and FLU1 has been linked to fluconazole resistance (White et al., 1998) and was investigated as a mechanism of resistance in our clinical isolates by using real-time RT-PCR.

References

Ref 1	Evaluation of fluconazole resistance mechanisms in candida albicans clinical isolates from HIV-infected patients in Brazil. Diagn Microbiol Infect Dis. 2004 Sep;50(1):25-32. doi: 10.1016/j.diagmicrobio.2004.04.009.