Molecule Information
General Information of the Molecule (ID: Mol00989)
Name |
L-lactate dehydrogenase B chain (LDHB)
,Homo sapiens
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Synonyms |
LDH-B; LDH heart subunit; LDH-H; Renal carcinoma antigen NY-REN-46
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Molecule Type |
Protein
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Gene Name |
LDHB
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Gene ID | |||||
Location |
chr12:21635342-21757857[-]
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Sequence |
MATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLK
GEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKF IIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLG IHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAY EVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARG LTSVINQKLKDDEVAQLKKSADTLWDIQKDLKDL Click to Show/Hide
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Uniprot ID | |||||
Ensembl ID | |||||
HGNC ID | |||||
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Type(s) of Resistant Mechanism of This Molecule
RTDM: Regulation by the Disease Microenvironment
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
Cetuximab
Drug Resistance Data Categorized by Their Corresponding Mechanisms | ||||
Regulation by the Disease Microenvironment (RTDM) | ||||
Disease Class: Colorectal cancer | [1] | |||
Resistant Disease | Colorectal cancer [ICD-11: 2B91.1] | |||
Resistant Drug | Cetuximab | |||
Molecule Alteration | Expression | Down-regulation |
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Experimental Note | Discovered Using In-vivo Testing Model | |||
Cell Pathway Regulation | Pentose phosphate signaling pathway | Activation | hsa00030 | |
In Vitro Model | SW480 cells | Colon | Homo sapiens (Human) | CVCL_0546 |
GEO cells | Colon | Homo sapiens (Human) | CVCL_0271 | |
In Vivo Model | Xenografts mouse model | Mus musculus | ||
Experiment for Molecule Alteration |
2D DIGE assay | |||
Mechanism Description | LDHB and PDHA1 were downregulated in GEO-CR tumor xenografts, similarly to the corresponding deregulations observed in the derived cell lines. Upregulation of G6PDH and transketolase (TkT) was also actually maintained in tumor xenografts. Indeed, PPP2CA expression in xenografted samples was similarly evaluated, demonstrating that protein downregulation in vivo was even more pronounced than that measured in GEO-CR cells. |
References
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