Molecule Information

General Information of the Molecule (ID: Mol00984)

Name	Lanosterol 14-alpha demethylase (ERG11) ,Candida tropicalis
Synonyms	CYPLI; Cytochrome P450 51; Cytochrome P450-14DM; Cytochrome P450-LIA1; Sterol 14-alpha demethylase; CYP51 Click to Show/Hide
Molecule Type	Protein
Gene Name	ERG11
Sequence	MAIVDTAIDGINYFLSLSLTQQITILVVFPFIYNIAWQLLYSLRKDRVPMVFYWIPWFGS AASYGMQPYEFFEKCRLKYGDVFSFMLLGKVMTVYLGPKGHEFIYNAKLSDVSAEEAYTH LTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKTYVPKIREEVLNYFVNDVSFKTKE RDHGVASVMKTQPEITIFTASRCLFGDEMRKSFDRSFAQLYADLDKGFTPINFVFPNLPL PHYWRRDAAQRKISAHYMKEIKRRRESGDIDPKRDLIDSLLVNSTYKDGVKMTDQEIANL LIGVLMGGQHTSASTSAWFLLHLAEQPQLQDDLYEELTNLLKEKGGDLNDLTYEDLQKLP LVNNTIKETLRMHMPLHSIFRKVMNPLRVPNTKYVIPKGHYVLVSAGYAHTSDRWFEHPE HFNPRRWESDDTKASAVSFNSEDTVDYGFGKISKGVSSPYLPFGGGRHRCIGEQFAYVQL GTILTTYIYNFKWRLNGDKVPDVDYQSMVTLPLEPAEIVWEKRDTCMV Click to Show/Hide
Function	Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. Click to Show/Hide
Uniprot ID	CP51_CANTR
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Fungi Phylum: Ascomycota Class: Saccharomycetes Order: Saccharomycetales Family: Debaryomycetaceae Genus: Candida Species: Candida tropicalis

Type(s) of Resistant Mechanism of This Molecule

ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Fluconazole

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Aberration of the Drug's Therapeutic Target (ADTT)		Click to Show/Hide
Disease Class: Candida krusei infection			[1]
Resistant Disease	Candida krusei infection [ICD-11: 1F23.4]		Disease Info
Resistant Drug	Fluconazole		Drug Info
Molecule Alteration	Missense mutation	p.Y132F
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Candida tropicalis strain		5482
Experiment for Molecule Alteration	DNA sequencing assay
Experiment for Drug Resistance	Disk diffusion method assay
Mechanism Description	Overexpression of CtERG11 associated with a missense mutation in this gene seemed to be responsible for the acquired azole resistance of this clinical isolate.

References

Ref 1	Mechanisms of azole resistance in a clinical isolate of Candida tropicalis. Antimicrob Agents Chemother. 2005 Nov;49(11):4608-15. doi: 10.1128/AAC.49.11.4608-4615.2005.