General Information of the Molecule (ID: Mol00926)
Name
DNA topoisomerase (ATP-hydrolyzing) (PARC) ,Mycoplasma hominis
Molecule Type
Protein
Gene Name
parC
Sequence
MKKDRKEEIQEVTENIIEKNMADIMSDRFGRYSKYIIQQRAIPDARDGLKPVQRRILYSM
WNLHLKNSEPFKKSARIVGDVIGRYHPHGDSSIYEALVRMAQDWKSNFPLIEMHGNKGSI
DDDPAAAMRYTESRLEKISELMLKDLDRKVVKMAPNFDDSEYEPIVLPALFPNLLVNGAK
GIAAGFATEIPPHNLGEVIDATIALIKNPTISIEELSEIVKGPDFPTGAIINGINEIKKA
LSSGQGRITISSKYHYVYDKKDESKIIGIEIIEIPFGVVKSKLVADIDAIAIDKKISGIK
EVLDQTDRNGISIFIQLEDGANADAIIAYLMNKTELSISYSYNMVAIDNNRPVILNLYSA
LIAYLSHLKEVNINGINYDLKKFKLRLEIVEGFIKVAEISDEVIHLIKESDNSKKGVILA
LMNKFKFSELQATAIAELRLYKLSRMDQIEFQEEKKNLEIQIENCNKLLNDKWEFNQYLI
KQLLEIKNQYSKPRLTEISDQKIDKEIDHKLLTKNEDFYLYITKDGYYKKISLKVYTSNE
LSTFKLKEEDNVFYFDKVNSLSKILFFTNLGNYFIIDCHLFKDCNWKDLGQHISSIVALE
SSEKIIRVIEITSFNNYANFILMSKLGYAKKVNLRDFENKSSLKTKTCMSFKDDNDELID
AQISNDEKMLFILLNNGMYHLVSENELKVGISLKARGIRLLLNLYKHPQLQVSGFITVSK
YNNIIYLTQGGYIKCWDTSKLESTTRNTPKMLFTPLKNNILGLQSLAVTLSNLKMLYTDN
NGNLAEYDWKFILKDKTKESKLLKLDYSFTNPGYFITPIKINELIEVDEIEQEKIRQEYQ
GYIDKNIELTAEHALIKKSYNQDIQHLNNEEQEELFQISTEDIELPNVSNNVNDNQKDKK
NIATKESVSQKIQEIEKIDLETIMQKIKQIKKK
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Uniprot ID
O52166_MYCHO
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Kingdom: N.A.
Phylum: Tenericutes
Class: .
Order: Mycoplasmoidales
Family: Metamycoplasmataceae
Genus: Metamycoplasma
Species: Metamycoplasma hominis
Type(s) of Resistant Mechanism of This Molecule
  EADR: Epigenetic Alteration of DNA, RNA or Protein
Drug Resistance Data Categorized by Drug
Approved Drug(s)
3 drug(s) in total
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Levofloxacin
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Disease Class: Mycoplasma hominis genital infection [1]
Resistant Disease Mycoplasma hominis genital infection [ICD-11: 1B2Z.7]
Resistant Drug Levofloxacin
Molecule Alteration Missense mutation
p.K134R
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycoplasma hominis ATCC 23114(PG21) 347256
Mycoplasma hominis isolate 2098
Experiment for
Molecule Alteration
Whole genome sequence assay
Mechanism Description The single amino acid mutation in ParC of MH may relate to the resistance to OFX and LVX and the high-level resistance to fluoroquinolones for MH is associated with mutations in both DNA gyrase and the ParC subunit of topoisomerase IV.
Disease Class: Mycoplasma hominis prostate cancer [1]
Resistant Disease Mycoplasma hominis prostate cancer [ICD-11: 2C82.Y]
Resistant Drug Levofloxacin
Molecule Alteration Missense mutation
p.K134R
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycoplasma hominis ATCC 23114(PG21) 347256
Mycoplasma hominis isolate 2098
Experiment for
Molecule Alteration
Whole genome sequence assay
Mechanism Description The single amino acid mutation in ParC of MH may relate to the resistance to OFX and LVX and the high-level resistance to fluoroquinolones for MH is associated with mutations in both DNA gyrase and the ParC subunit of topoisomerase IV.
Disease Class: Mycoplasma hominis mycoplasma infection [1]
Resistant Disease Mycoplasma hominis mycoplasma infection [ICD-11: 1B2Z.4]
Resistant Drug Levofloxacin
Molecule Alteration Missense mutation
p.K134R
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycoplasma hominis ATCC 23114(PG21) 347256
Mycoplasma hominis isolate 2098
Experiment for
Molecule Alteration
Whole genome sequence assay
Mechanism Description The single amino acid mutation in ParC of MH may relate to the resistance to OFX and LVX and the high-level resistance to fluoroquinolones for MH is associated with mutations in both DNA gyrase and the ParC subunit of topoisomerase IV.
Ofloxacin
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Disease Class: Mycoplasma hominis genital infection [1]
Resistant Disease Mycoplasma hominis genital infection [ICD-11: 1B2Z.7]
Resistant Drug Ofloxacin
Molecule Alteration Missense mutation
p.K134R
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycoplasma hominis ATCC 23114(PG21) 347256
Mycoplasma hominis isolate 2098
Experiment for
Molecule Alteration
Whole genome sequence assay
Mechanism Description The single amino acid mutation in ParC of MH may relate to the resistance to OFX and LVX and the high-level resistance to fluoroquinolones for MH is associated with mutations in both DNA gyrase and the ParC subunit of topoisomerase IV.
Disease Class: Mycoplasma hominis prostate cancer [1]
Resistant Disease Mycoplasma hominis prostate cancer [ICD-11: 2C82.Y]
Resistant Drug Ofloxacin
Molecule Alteration Missense mutation
p.K134R
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycoplasma hominis ATCC 23114(PG21) 347256
Mycoplasma hominis isolate 2098
Experiment for
Molecule Alteration
Whole genome sequence assay
Mechanism Description The single amino acid mutation in ParC of MH may relate to the resistance to OFX and LVX and the high-level resistance to fluoroquinolones for MH is associated with mutations in both DNA gyrase and the ParC subunit of topoisomerase IV.
Disease Class: Mycoplasma hominis mycoplasma infection [1]
Resistant Disease Mycoplasma hominis mycoplasma infection [ICD-11: 1B2Z.4]
Resistant Drug Ofloxacin
Molecule Alteration Missense mutation
p.K134R
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycoplasma hominis ATCC 23114(PG21) 347256
Mycoplasma hominis isolate 2098
Experiment for
Molecule Alteration
Whole genome sequence assay
Mechanism Description The single amino acid mutation in ParC of MH may relate to the resistance to OFX and LVX and the high-level resistance to fluoroquinolones for MH is associated with mutations in both DNA gyrase and the ParC subunit of topoisomerase IV.
Sparfloxacin
Click to Show/Hide
Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Disease Class: Mycoplasma hominis genital infection [1]
Resistant Disease Mycoplasma hominis genital infection [ICD-11: 1B2Z.7]
Resistant Drug Sparfloxacin
Molecule Alteration Missense mutation
p.K134R
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycoplasma hominis ATCC 23114(PG21) 347256
Mycoplasma hominis isolate 2098
Experiment for
Molecule Alteration
Whole genome sequence assay
Mechanism Description The single amino acid mutation in ParC of MH may relate to the resistance to OFX and LVX and the high-level resistance to fluoroquinolones for MH is associated with mutations in both DNA gyrase and the ParC subunit of topoisomerase IV.
Disease Class: Mycoplasma hominis prostate cancer [1]
Resistant Disease Mycoplasma hominis prostate cancer [ICD-11: 2C82.Y]
Resistant Drug Sparfloxacin
Molecule Alteration Missense mutation
p.K134R
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycoplasma hominis ATCC 23114(PG21) 347256
Mycoplasma hominis isolate 2098
Experiment for
Molecule Alteration
Whole genome sequence assay
Mechanism Description The single amino acid mutation in ParC of MH may relate to the resistance to OFX and LVX and the high-level resistance to fluoroquinolones for MH is associated with mutations in both DNA gyrase and the ParC subunit of topoisomerase IV.
Disease Class: Mycoplasma hominis mycoplasma infection [1]
Resistant Disease Mycoplasma hominis mycoplasma infection [ICD-11: 1B2Z.4]
Resistant Drug Sparfloxacin
Molecule Alteration Missense mutation
p.K134R
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycoplasma hominis ATCC 23114(PG21) 347256
Mycoplasma hominis isolate 2098
Experiment for
Molecule Alteration
Whole genome sequence assay
Mechanism Description The single amino acid mutation in ParC of MH may relate to the resistance to OFX and LVX and the high-level resistance to fluoroquinolones for MH is associated with mutations in both DNA gyrase and the ParC subunit of topoisomerase IV.
References
Ref 1 Molecular mechanism of fluoroquinolones resistance in Mycoplasma hominis clinical isolates. Braz J Microbiol. 2014 May 19;45(1):239-42. doi: 10.1590/s1517-83822014000100034. eCollection 2014.

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