Molecule Information

General Information of the Molecule (ID: Mol00891)

• Name: D-glucan-1,3-beta--UDP glucosyltransferase (FKS1) ,Candida parapsilosis
• Synonyms: FKS1; EC 2.4.1.34
• Molecule Type: Protein
• Gene Name: FKS1
• Sequence:
  MSYNDNNHNYYDPNQQGGGVPNDGYYQQPYDMNQQQQQQQQQPYDDMNQQPQHQDYYDPN
  AQYHQQPYDMDGYNDPNQYGGHPMNAQGYNADPEAFSDFSYNGQAPGTPGYDQYGTQYTP
  SQMSYGGDPRSSGASTPIYGVQGQGYDPTQFQVSSNLPYPAWSADPQAPIKIEHIEDIFI
  DLTNKFGFQRDSMRNMFDYFMTLLDSRSSRMAPAQALLSLHADYIGGDNANYRKWFFSSQ
  QDLDDTLGFANMTLGKIGRKARKASKKSKKARKAAEEHGEDVDALANELEGDYSLEAAEI
  RWKAKMNTLTPEERVRDIALYLLLWGEANQVRFTPECLCYLYKTAVDYLESPLCQQRQEP
  VPEGDYLNRVITPLYRFLRSQVYEIYEGRFVKREKDHNKVIGYDDVNQLFWYPEGVSRII
  FTDGTRLIDIPKEERYLRLGEVEWSNVFFKTYKEIRTWLHFVTNFNRIWIIHGSIYWMYT
  AYNSPTLYTKNYVQTINQQPLASSRWAACAIGGIIAAFLQILATIFEWMFVPREWAGAQH
  LTRRLMFLILIFLVNLAPVVYTFKVAGLTLYSKSSYALSVVGFFIAVATLVFFAVMPLGG
  LFTSYMNKRSRRYISSHTFTANFVKLRGLDMWMSYLLWVLVFLAKLVESYFFLTLSLRDA
  IRNLSKTTMRCTGEVWYGDIVCRQQAKIVLGLMYAVDLLLFFLDTYLWYIICNCIFSIGR
  SFYLGISILTPWRNIFTRLPKRIYSKILATTEMEIKYKPKVLISQIWNAIVISMYREHLL
  AIDHVQKLLYHQVPSEIEGKRTLRAPTFFASQDDNNFETEFFPRNSEAERRISFFAQSLA
  TPMPEPVPVDNMPTFTVFTPHYSEKILLSLREIIREDDQFSRVTLLEYLKQLHPVEWECF
  VKDTKILAEETAAYENGEDAEKASEDGLKSKIDDLPFYCIGFKSAAPEYTLRTRIWASLR
  SQTLYRTVSGFMNYARAIKLLYRVENPELVQYFGGDPEGLELALEKMARRKFRFLVSMQR
  LSKFKDDEMENAEFLLRAYPDLQIAFLDEEPALNEDEEPRVYSSLIDGHCEMLENGRRRP
  KFRVQLSGNPILGDGKSDNQNHAIIFHRGEYIQLIDANQDNYLEECLKIRSVLAEFEELN
  VEHVNPYSPDLKSENPLHEKKAPVAILGAREYIFSENSGVLGDVAAGKEQTFGTLFARTL
  AQIGGKLHYGHPDFLNATFMLTRGGVSKAQKGLHLNEDIYAGMNAMMRGGKIKHCEYYQC
  GKGRDMGFGSILNFTTKIGAGMGEQMLSREYYYLSTQLPLDRFLSFYYGHPGFHINNLFI
  QLSLQVFMLVLANLNSLAHESIICSYDRDVPVTDVLYPFGCYNIAPAVDWIRRYTLSIFI
  VFFISFIPLVVQELIERGVWKACQRFVRHFISLSPMFEVFVAQIYSSSVFTDLTVGGARY
  ISTGRGFATSRIPFSILYSRFADSSIYMGARLMLILLFGTVAHWQAPLLWFWASLSSLMF
  SPFIFNPHQFAWEDFFIDYRDFIRWLSRGNTKWHRNSWIGYVRLSRSRITGFKRKLTGDI
  SEKAAGDASRAHRSNILFADFLPTLIYTAGLYVAFTFINAQTGVTQYPYEIDGSTDVQEV
  NSVLRLIVCSLAPVVIDCGVLFGCVGMACCAGPMMGLCCKKTGAVIAGIAHGIAVIVHIV
  FFIVMWVMEGFNFARMLLGFATMIYVQRLLFKFLTLAFLTREFKNDKANTAFWTGKWYNT
  GMGWMAFTQPSREFVAKIVEMSEFAGDFMLAHIILFCQLPILAVPLIDRWHSMMLFWLKP
  SRLIRPPIYSLKQARLRKRMVRKYVTLYFAVLLLFVVIIAAPAAASGSIKVDQFADIGSK
  GSIAYGLFQPRNVSNNDTGPTNRPKSYTWSYLSEKYSGHTTAYSTNAFR
• Uniprot ID: A9YLC3_CANPA

Kingdom: Fungi
Phylum: Ascomycota
Class: Saccharomycetes
Order: Saccharomycetales
Family: Debaryomycetaceae
Genus: Candida
Species: Candida parapsilosis

Type(s) of Resistant Mechanism of This Molecule

  ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Drug

Approved Drug(s) 3 drug(s) in total

Anidulafungin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Aberration of the Drug's Therapeutic Target (ADTT)

Disease Class: Invasive candidiasis [1]

• Resistant Disease: Invasive candidiasis [ICD-11: 1F23.5]
• Resistant Drug: Anidulafungin
• Molecule Alteration: Missense mutation; p.P660A
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Candida parapsilosis strain; 5480
• Experiment for Molecule Alteration: DNA sequencing assay
• Experiment for Drug Resistance: M27-A2 broth dilution method assay
• Mechanism Description: Overall, these data firmly indicate that a naturally occurring P660A substitution in Fks1p from the C. parapsilosis group accounts for the reduced susceptibility phenotype.

Caspofungin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Aberration of the Drug's Therapeutic Target (ADTT)

Disease Class: Invasive candidiasis [1]

• Resistant Disease: Invasive candidiasis [ICD-11: 1F23.5]
• Resistant Drug: Caspofungin
• Molecule Alteration: Missense mutation; p.P660A
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Candida parapsilosis strain; 5480
• Experiment for Molecule Alteration: DNA sequencing assay
• Experiment for Drug Resistance: M27-A2 broth dilution method assay
• Mechanism Description: Overall, these data firmly indicate that a naturally occurring P660A substitution in Fks1p from the C. parapsilosis group accounts for the reduced susceptibility phenotype.

Micafungin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Aberration of the Drug's Therapeutic Target (ADTT)

Disease Class: Invasive candidiasis [1]

• Resistant Disease: Invasive candidiasis [ICD-11: 1F23.5]
• Resistant Drug: Micafungin
• Molecule Alteration: Missense mutation; p.P660A
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Candida parapsilosis strain; 5480
• Experiment for Molecule Alteration: DNA sequencing assay
• Experiment for Drug Resistance: M27-A2 broth dilution method assay
• Mechanism Description: Overall, these data firmly indicate that a naturally occurring P660A substitution in Fks1p from the C. parapsilosis group accounts for the reduced susceptibility phenotype.

References

• Ref 1: A naturally occurring proline-to-alanine amino acid change in Fks1p in Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis accounts for reduced echinocandin susceptibility. Antimicrob Agents Chemother. 2008 Jul;52(7):2305-12. doi: 10.1128/AAC.00262-08. Epub 2008 Apr 28.